Early Detection and Successful Treatment of Vertically Transmitted Fulminant Enteroviral Infection Associated with Various Forms of Arrhythmia and Severe Hepatitis with Coagulopathy

Q3 Medicine

Pediatric Infection and Vaccine Pub Date : 2019-12-01 DOI:10.14776/PIV.2019.26.E16

So Ra Lee, S. Y. Ko, S. Yoon, Yeon Kyung Lee, S. Shin

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引用次数: 1

Abstract

Enteroviral infections are common in neonates. One important infection pathway is vertical transmission from an infected mother to her neonate. Here, we report the early detection and successful treatment of a vertically transmitted fulminant enteroviral infection associated with myocarditis and hepatitis. The patient had a sudden onset of high fever on the 4th day of life and showed severe, rapidly progressing symptoms of disseminated intravascular coagulopathy (DIC), hepatitis, and myocarditis accompanied by tachyarrhythmia. As it was the peak season for enteroviral infections and both the mother and the patient's 36-month-old sibling had a high fever around the time of delivery, we suspected enteroviral infection. Thus, we began prompt evaluation for enteroviral infection, as well as close observation and intensive care of the neonate. We strongly recommend evaluation for the possibility of enterovirus vertical infection in neonates when the mother is suspected of having a viral infection (e.g., high fever and negative results from bacterial infectious studies) around the time of delivery and when the neonate shows some early indication of infectious diseases such as thrombocytopenia, DIC, hepatitis, and myocarditis. Early detection of enteroviral infections and prompt implementation of proper treatment are key to reducing the risk of complications and mortality associated with enteroviral infections in neonates.

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垂直传播暴发性肠道病毒感染并发各种形式心律失常和重型肝炎合并凝血障碍的早期发现和成功治疗

肠道病毒感染在新生儿中很常见。一个重要的感染途径是从受感染的母亲到她的新生儿的垂直传播。在此，我们报告了与心肌炎和肝炎相关的垂直传播的暴发性肠病毒感染的早期发现和成功治疗。患者在出生第4天突然出现高热，并表现出严重且进展迅速的弥散性血管内凝血病(DIC)、肝炎和心肌炎伴速性心律失常。由于这是肠道病毒感染的高发季节，母亲和患者36个月大的兄弟姐妹在分娩前后都有高烧，我们怀疑是肠道病毒感染。因此，我们开始及时评估肠道病毒感染，并对新生儿进行密切观察和重症监护。我们强烈建议在分娩前后，当母亲怀疑患有病毒感染(例如，高烧和细菌感染检查结果阴性)，以及当新生儿出现一些早期传染病指征，如血小板减少症、DIC、肝炎和心肌炎时，对新生儿肠病毒垂直感染的可能性进行评估。早期发现肠道病毒感染并及时实施适当治疗是降低新生儿肠道病毒感染相关并发症和死亡风险的关键。

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来源期刊

Pediatric Infection and Vaccine Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： Pediatric Infection and Vaccine is an official publication of the Korean Society of Pediatric Infectious Diseases and a peer-reviewed, open-access, multidisciplinary journal directed to physicians and other health care professionals who manage infectious diseases of childhood. The editorial board calls for the articles that originate from worldwide research or clinical study groups and the publication is determined by the editors and reviewers who are the experts in the specific field of infectious diseases of childhood. The categories of manuscripts are original articles, case reports, reviews and rapid communication. The Journal is published triannually and distributed to members of the Korean Society of Pediatric Infectious Diseases, medical schools, libraries and related institutes to persue the academic advancement in infectious diseases and to promote active communication between the members and international societies of pediatric infectious diseases. Eventually, the journal aims to contribute to the cure of infectious diseases of childhood and to the improvement of public health.