Protein nanoparticles as natural drugs carriers for cancer therapy

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Sara Zaher, Mahmoud E. Soliman, Mahmoud Elsabahy, Rania M. Hathout
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引用次数: 5

Abstract

Nanoscale drug carriers are useful in improving the bioavilability, targeting delivery, and controlling the release of the loaded drug. Polymers from natural sources possess favourable properties such as adaptability and safety for usage as nanosized drug delivery carriers and as substitutes of synthetic polymers. The use of a biomaterial imparts special biopharmaceutical characteristics to the formulation and changes the pharmacokinetic and pharmacodynamic profile of the entrapped medication. Proteins appear as promising raw materials in this approach because of their extensive availability from renewable sources, low cost, and ability to be chemically modified, ligand conjugation and degraded into harmless by-products. Furthermore, protein nanocarriers have several benefits, including high drug-binding capability and specific tumour targeting using different ligands. This review discusses the properties of different protein biopolymers such as albumin, gelatin, zein, gliadin, casein, collagen, elastin and whey protein. The study focuses on the most relevant applications of the protein nanoparticles loading agents with antitumeric effect. Furthermore, the review summarises the primary findings of tumour-targeted protein nanoparticles in vitro and in vivo studies.

蛋白质纳米粒子作为癌症治疗的天然药物载体
纳米药物载体在提高药物的生物利用度、靶向递送和控制药物释放方面具有重要意义。天然来源的聚合物具有良好的特性,如适应性和安全性,可作为纳米级药物输送载体和合成聚合物的替代品。生物材料的使用赋予制剂特殊的生物制药特性,并改变被包裹药物的药代动力学和药效学特征。在这种方法中,蛋白质似乎是很有前途的原材料,因为它们可广泛地从可再生资源中获得,成本低,并且能够进行化学修饰,配体偶联并降解为无害的副产物。此外,蛋白质纳米载体有几个好处,包括高药物结合能力和使用不同配体的特异性肿瘤靶向。本文综述了白蛋白、明胶、玉米蛋白、麦胶蛋白、酪蛋白、胶原蛋白、弹性蛋白和乳清蛋白等不同的蛋白质生物聚合物的特性。研究了具有抗肿瘤作用的蛋白质纳米颗粒装载剂的最相关应用。此外,本文还总结了肿瘤靶向蛋白纳米颗粒在体外和体内研究中的主要发现。
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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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