Omeprazole vs Lansoprazole in the Management of Gastroesophageal Reflux Disease: A Systematic Literature Review

Journal of medical research and innovation Pub Date : 2020-03-29 DOI:10.32892/jmri.204

Mamoona Javed, Muhammad Hayder Ali, M. Tanveer, M. Tanveer

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引用次数: 2

Abstract

Objective: To evaluate the effectiveness and safety of omeprazole compared to lansoprazole in Gastroesophageal reflux disease patients (GERD). Methods: A systematic search of MEDLINE, EMBASE (inception to December 2019) and CENTRAL (January 2011 to December 2019) was conducted to identify the relevant articles. A detailed inclusion-exclusion criterion was developed and implemented to screen the abstracts. Full texts of the selected abstracts were then assessed to establish their inclusion or exclusion in our review. Cochrane risk of bias criterion was used to assess the methodological quality of the included studies. All relevant data were extracted and the results were summarised narratively. Results: 9 studies met our inclusion-exclusion criteria and were included in this review. In all three trials reporting on heartburn and regurgitation, both omeprazole and lansoprazole were found to be effective in relieving the symptoms of heartburn and regurgitation; however, there was no evidence that one is better than the other. Five out of six studies reporting on intragastric pH provided the evidence of omeprazole’s superiority over lansoprazole in controlling gastric pH. Omeprazole lowered intragastric pH faster and the results lasted longer compared to lansoprazole. The results were statistically significant. Conclusion: There is no significant difference in the clinical effectiveness of omeprazole and lansoprazole in relieving symptoms of heartburn and regurgitation. However, omeprazole is more effective in reducing gastric acidity than lansoprazole.

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奥美拉唑与兰索拉唑治疗胃食管反流病:系统文献综述

目的：评价奥美拉唑与兰索拉唑治疗胃食管反流病（GERD）的有效性和安全性。方法：系统检索MEDLINE、EMBASE（起始至2019年12月）和CENTRAL（2011年1月至2019年2月），以确定相关文章。为了筛选摘要，制定并实施了详细的纳入-排除标准。然后对所选摘要的全文进行评估，以确定它们是否包含在我们的综述中。采用Cochrane偏倚风险标准评估纳入研究的方法学质量。提取了所有相关数据，并对结果进行了叙述性总结。结果：9项研究符合我们的纳入-排除标准，被纳入本综述。在报告胃灼热和反流的所有三项试验中，奥美拉唑和兰索拉唑都被发现能有效缓解胃灼热和反流症状；然而，没有证据表明一个比另一个好。六项关于胃内pH值的研究中有五项证明奥美拉唑在控制胃内pH方面优于兰索拉唑。与兰索拉唑相比，奥美拉唑降低胃内pH更快，结果持续时间更长。结果具有统计学意义。结论：奥美拉唑与兰索拉唑治疗胃灼热、反胃症状的临床疗效无显著差异。然而，奥美拉唑在降低胃酸方面比兰索拉唑更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of medical research and innovation

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