A Systematic Review on the Impact of Micro-Nanoplastics Exposure on Human Health and Diseases

Q3 Biochemistry, Genetics and Molecular Biology

Biointerface Research in Applied Chemistry Pub Date : 2022-10-31 DOI:10.33263/briac134.381

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引用次数: 1

Abstract

Plastic production is continuously increasing worldwide for daily use. Micro-plastics and nano-plastics remain major emerging pollutants and threaten the environment, ecosystem, human health, and well-being. Micro-nanoplastics (MNPs) are also exposed to humans through cosmetics, inhalation, ingestion, drinking water, dietary sources, and drug formulations. Oral uptake is the major among the different exposure routes of MNPs to humans. After entry, it gets absorbed due to its nano size (˂100 nm) and easily distributed to all parts of the body through blood, affecting multiple organs, especially vital organs of the human body leading to severe diseases. It causes cancer, heart, liver, and kidney diseases, crosses the blood-brain barrier, and affects the brain. Its adsorption with protein leads to multi-layered corona formation in human blood plasma. MNPs interact with immune cells and induce pro-inflammatory mediators, inflammatory reactions, reactive oxygen species (ROS) production, and associated cytotoxicity. MNPs suppress T lymphocyte activity which results in a lack of immune regulation leading to autoimmune diseases. Hence, it is necessary to understand the impact of MNPs exposure on humans. Strict control measures for the production and use of plastics and developing appropriate strategies for safe disposal would prevent MNPs-mediated toxicity in humans.

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微纳米塑料暴露对人类健康和疾病影响的系统评价

全世界日常使用的塑料产量不断增加。微塑料和纳米塑料仍然是主要的新兴污染物，威胁着环境、生态系统、人类健康和福祉。微纳米塑料（MNPs）也通过化妆品、吸入、摄入、饮用水、饮食来源和药物配方暴露于人类。在MNPs对人类的不同暴露途径中，口服摄取是主要的。进入后，由于其纳米尺寸（100 nm），它被吸收，并容易通过血液分布到身体的各个部位，影响多个器官，尤其是人体的重要器官，从而导致严重疾病。它会导致癌症、心脏、肝脏和肾脏疾病，穿过血脑屏障，影响大脑。它与蛋白质的吸附导致人类血浆中形成多层电晕。MNPs与免疫细胞相互作用，诱导促炎介质、炎症反应、活性氧（ROS）产生和相关的细胞毒性。MNPs抑制T淋巴细胞活性，导致缺乏免疫调节，从而导致自身免疫性疾病。因此，有必要了解MNPs暴露对人类的影响。对塑料的生产和使用采取严格的控制措施，并制定适当的安全处置战略，将防止MNPs介导的人类毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biointerface Research in Applied Chemistry CHEMISTRY, APPLIED-

CiteScore

4.80

自引率

0.00%

发文量

256

期刊介绍： Biointerface Research in Applied Chemistry is an international and interdisciplinary research journal that focuses on all aspects of nanoscience, bioscience and applied chemistry. Submissions are solicited in all topical areas, ranging from basic aspects of the science materials to practical applications of such materials. With 6 issues per year, the first one published on the 15th of February of 2011, Biointerface Research in Applied Chemistry is an open-access journal, making all research results freely available online. The aim is to publish original papers, short communications as well as review papers highlighting interdisciplinary research, the potential applications of the molecules and materials in the bio-field. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible.