The role of immune cells in therapeutic angiogenesis: Concepts in tissue engineering

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL

Current Opinion in Biomedical Engineering Pub Date : 2023-05-29 DOI:10.1016/j.cobme.2023.100470

Zoleikha Azari , Sara Gorgani , Seyede Atefe Hosseini , Andrew Z. Wang , Hae-Won Kim , Saeid Kargozar

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引用次数: 2

Abstract

Immune cells can positively regulate new blood vessel formation by secreting proangiogenic mediators and modulating endothelial cell (EC) and endothelial progenitor cell (EPC) activities (e.g., homing). Accordingly, timely management of immune cell behavior is performed to promote angiogenesis and accelerate tissue healing. Different characteristics of biomaterials and scaffolds, including chemical (e.g., composition) and physical (e.g., topography) properties, were proven to influence the angiogenic potential of immune cells. Moreover, specific biomolecular cargoes can be loaded into 3D scaffolds to affect immune cells' behavior in favor of improved angiogenesis. Excess neovascularization can cause pathological conditions, thus establishing a balance between pro- and anti-angiogenic mediators should be taken into account once developing biomaterials and scaffolds for modulating immune cell activities. This review provides an in-depth and concise review of the angiogenic-regulatory effects of immune cells and discusses the importance of its modulation by biomaterials and scaffolds for tissue engineering.

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免疫细胞在治疗性血管生成中的作用:组织工程中的概念

免疫细胞可以通过分泌促血管生成介质和调节内皮细胞(EC)和内皮祖细胞(EPC)的活性(如归巢)来积极调节新血管的形成。因此，及时管理免疫细胞的行为，以促进血管生成和加速组织愈合。生物材料和支架的不同特性，包括化学(如组成)和物理(如地形)特性，已被证明会影响免疫细胞的血管生成潜能。此外，特定的生物分子货物可以装载到3D支架中，以影响免疫细胞的行为，有利于改善血管生成。过多的新生血管可引起病理状况，因此在开发调节免疫细胞活性的生物材料和支架时，应考虑在促血管生成介质和抗血管生成介质之间建立平衡。本文对免疫细胞的血管生成调节作用进行了深入和简明的综述，并讨论了生物材料和支架在组织工程中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

8.60

自引率

2.60%

发文量