Gustav Eriksson, Mats Hulander, Mattias Thuvander, Martin Andersson
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引用次数: 0
Abstract
Titanium is commonly used for medical devices, including osseointegrating implants, owing to its biocompatibility and mechanical properties. Nanostructuring titanium implants is known to enhance the healing process by promoting bone growth on the implant surface. Hydroxyapatite nanoparticles, resembling natural bone mineral, have been used to further improve osseointegration. While previous studies have investigated the osseointegration of titanium implants using atom probe tomography, limited research has focused on the attachment of synthetic hydroxyapatite to titanium. Herein, electron microscopy and atom probe tomography are used to reveal the assembly of synthetic hydroxyapatite nanoparticles in the titanium oxide surface. By sputter coating with chromium, a suitable matrix is formed for detailed interfacial analysis. The results demonstrate the diffusion of calcium, phosphorus, and carbon from hydroxyapatite nanoparticles into the titanium oxide surface.
期刊介绍：
Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science.
The scope of Advanced NanoBiomed Research will cover the following key subject areas:
▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging.
▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications.
▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture.
▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs.
▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization.
▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems.
with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.
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