Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology

IF 8.6 2区化学 Q1 Chemistry

Topics in Current Chemistry Pub Date : 2021-04-22 DOI:10.1007/s41061-021-00335-9

Lin-Sheng Zhuo, Ming-Shu Wang, Jing-Fang Yang, Hong-Chuang Xu, Wei Huang, Lu-Qing Shang, Guang-Fu Yang

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引用次数: 4

Abstract

Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a pandemic around the world. Currently, specific antiviral drugs to control the epidemic remain deficient. Understanding the details of SARS-CoV-2 structural biology is extremely important for development of antiviral agents that will enable regulation of its life cycle. This review focuses on the structural biology and medicinal chemistry of various key proteins (Spike, ACE2, TMPRSS2, RdRp and M^pro) in the life cycle of SARS-CoV-2, as well as their inhibitors/drug candidates. Representative broad-spectrum antiviral drugs, especially those against the homologous virus SARS-CoV, are summarized with the expectation they will drive the development of effective, broad-spectrum inhibitors against coronaviruses. We are hopeful that this review will be a useful aid for discovery of novel, potent anti-SARS-CoV-2 drugs with excellent therapeutic results in the near future.

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洞察SARS-CoV-2:对抗其结构和功能生物学的药物化学方法

由严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)引起的2019冠状病毒病仍在全球范围内流行。目前，控制该流行病的特异性抗病毒药物仍然缺乏。了解SARS-CoV-2结构生物学的细节对于开发能够调节其生命周期的抗病毒药物非常重要。本文综述了SARS-CoV-2生命周期中各种关键蛋白(Spike、ACE2、TMPRSS2、RdRp和Mpro)及其抑制剂/候选药物的结构生物学和药物化学。总结了代表性的广谱抗病毒药物，特别是针对同源病毒SARS-CoV的广谱抗病毒药物，并期望它们将推动有效的广谱抗冠状病毒抑制剂的开发。我们希望这一综述将有助于在不久的将来发现新的、有效的抗sars - cov -2药物，并取得良好的治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Current Chemistry 化学-化学综合

CiteScore

11.70

自引率

1.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.