Click-Chemistry-Assisted Alteration of Glycosaminoglycans for Biological Applications

IF 2 Q2 CHEMISTRY, ORGANIC
SynOpen Pub Date : 2023-03-03 DOI:10.1055/s-0040-1720072
Smritilekha Bera, D. Mondal
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引用次数: 0

Abstract

This short review describes the assistance of click chemistry in the chemical modification of glycosaminoglycans. Through an alkyne-azide 1,3-dipolar cycloaddition reaction, the chemically and physiologically stable triazole unit connects glycosaminoglycans with other labelled or attached functionalities. The synthesized glycosaminoglycan (GAG) conjugates act as drug carriers, forming hydrogels or nanohydrogels for localized drug delivery or injectable GAGs and so on. These are used in research on antithrombotic agents, protein binding, and hepatocyte growth factors, as well as in mechanistic studies of glycosaminoglycans biosynthesis and wound healing.1 Introduction2 Synthetic Modification of GAGS3 Click Chemistry4 Modification of GAGS Applying Click Chemistry5 Conclusions6 Abbreviations

Abstract Image

生物应用中糖胺聚糖的点击化学辅助修饰
本文简要介绍了点击化学在糖胺聚糖化学改性中的作用。通过炔-叠氮化1,3偶极环加成反应,化学上和生理上稳定的三唑单元将糖胺聚糖与其他标记或附加的官能团连接起来。合成的糖胺聚糖(GAG)偶联物作为药物载体,形成水凝胶或纳米水凝胶,用于局部药物递送或可注射的GAG等。它们被用于抗血栓药物、蛋白质结合和肝细胞生长因子的研究,以及糖胺聚糖生物合成和伤口愈合的机制研究引言2 GAGS的合成修饰s3 Click化学4应用Click化学修饰GAGS 5结论6缩写
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
SynOpen
SynOpen CHEMISTRY, ORGANIC-
CiteScore
2.30
自引率
4.00%
发文量
35
审稿时长
6 weeks
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