IMPACT OF ANTI-TUBERCULOSIS DRUGS ON THE EXPRESSION OF CYTOCHROME-ASSOCIATED GENES

Abstract

The impact of Tuberculosis (TB) drugs on liver and kidney bio-indicators as well as histological architecture has been investigated since the inception of the drugs, with little or no sufficient data on the impact of the drugs at gene or molecular level. High through put analysis such as Real-Time Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR), Microarray, Proteomics, Nano-strings and Next generation Sequencing (NGS) are normally employed to ascertain the level of damage cause by the drugs at molecular level. As such the expression levels of the genes can be determined, whether they are up regulated or down regulated, and compared the fold change with samples of the control group. The up regulation or down regulation of gene due to chemotherapy is an indicator of anomaly in a particular gene, and that can lead to the malfunction of the affected gene. The up regulation of gland secretion gene can lead to over secretion of hormone and also down regulation can lead to under secretion, and the overall biological process taking place in body can be halt and some biological functions can be obstructed. This review is aimed at investigating the impact of anti-tuberculosis drugs on the expression of cytochrome-associated genes, and to elaborate how some of the physiological processes of the body are affected by the up regulated or down regulated genes.