P.31 Von Willebrand Factor Induces Vascular Smooth Muscle Cell Proliferation and Migration Through Low Density Lipoprotein-Related Receptor Protein 4 and αvβ3 Integrin

IF 0.9 4区医学 Q4 PERIPHERAL VASCULAR DISEASE

Artery Research Pub Date : 2020-12-01 DOI:10.2991/artres.k.201209.044

C. Denis, P. Lacolley, J. Lagrange, P. Lenting, J. Michel, A. Raoul, V. Regnault

引用次数: 0

Abstract

Background and Objectives: Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary hemostasis but recent data suggest additional roles beyond hemostasis in angiogenesis and potentially in vascular smooth muscle cell (VSMC) proliferation. Our aim was to investigate how VWF can modulate VSMC proliferation and identified the underlying mechanisms and the in vivo pathophysiological relevance.

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P.31血管性血友病因子通过低密度脂蛋白相关受体蛋白4和αvβ3整合素诱导血管平滑肌细胞增殖和迁移

背景和目的：血管性血友病因子（VWF）是一种参与原发性止血的血浆糖蛋白，但最近的数据表明，除了止血之外，它在血管生成中还有其他作用，并可能在血管平滑肌细胞（VSMC）增殖中发挥作用。我们的目的是研究VWF如何调节VSMC增殖，并确定其潜在机制和体内病理生理相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artery Research Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.70

自引率

16.70%

发文量

审稿时长

13 weeks

期刊介绍： Artery Research is the official journal of the Association for Research into Arterial Structure and Physiology (ARTERY) which promotes the advancement of knowledge and dissemination of information concerning the pathophysiology, epidemiology, detection, investigation and treatment of arterial structure and function. The journal publishes original research articles, review articles, perspectives, case-studies, letters to the Editor, short communications and images. All submitted material is subject to a strict peer-review process.