Antiplasmodial Activity of Phyllanthus amarus and Associated Impact on Surrogate Markers of Insulin Sensitivity and Resistance Indices

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2022-09-13 DOI:10.1080/10496475.2022.2122101

A. O. Opajobi, U. Uzuegbu, C. Elu, P. Y. Toloyai, I. Igwenyi, I. Onyesom

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Abstract

ABSTRACT The antimalarial activity of different parts (leaf, fruit, stem, and root) of Phyllanthus amarus and their associated impact on surrogate markers of insulin sensitivity in experimental mice, having ascertained their toxicity (LD50) index were documented. Results showed that the plant parts were nontoxic (LD50 > 5,000 mg kg−1) and were antimalarial in a dose-dependent manner, with the ethanol leaf extract having the highest parasite suppression followed by the fruit, root, and stem extracts. However, the root extract had the most profound impact on insulin sensitivity compared to other parts, although all showed improvement, with insulin sensitivity/resistance indices, with QUICKI vs. HOMA-IR showing a strong positive correlation (r = 0.993), but QUICKI vs. HOMA-IR and HOMA-IR vs. 1/HOMA = IR having strong negative correlation (r = −0.963 and −0.927, respectively). So, QUICKI and 1/HOMA-IR are surrogate indices of insulin sensitivity and HOMA-IR and TyG index, insulin resistance surrogate markers.

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苦叶下珠的抗疟原虫活性及其对胰岛素敏感性和抗性指标替代标记的影响

摘要:本文研究了毛兰不同部位(叶、果、茎、根)的抗疟活性及其对实验小鼠胰岛素敏感性替代标志物的影响，并确定了其毒性(LD50)指数。结果表明，该植物部分无毒(LD50 ~ 5000 mg kg - 1)，且呈剂量依赖性，其中乙醇提取物对寄生虫的抑制作用最强，其次是果实、根和茎提取物。而与其他部位相比，根提取物对胰岛素敏感性的影响最为深远，虽然均有改善，但胰岛素敏感性/抵抗指标，QUICKI与HOMA-IR呈强正相关(r = 0.993)，而QUICKI与HOMA-IR和HOMA-IR与1/HOMA = IR呈强负相关(r分别= - 0.963和- 0.927)。因此，QUICKI和1/HOMA-IR是胰岛素敏感性的替代指标，HOMA-IR和TyG指数是胰岛素抵抗的替代指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.