Protective Effect of Enterococcus faecium SF68 and Saccharomyces boulardii in Acute Severe Diarrhea in Infants: Randomized Controlled Trial

Esculapio Pub Date : 2021-01-29 DOI:10.51273/ESC20.2516413

Fariha Khan, M. Z. Khan, A. M. Rehan, Zoobia Irum, F. Perveen, S. Chiragh

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Abstract

Objectives: This study was done to observe the effect of Enterococcus faecium SF68 and Saccharomyces boulardii in acute severe diarrhea in infants. Methods: It was a single blind, randomized controlled clinical trial done in Children Hospital, Lahore. The infants were selected between 6 months to 12 months of age. All the infants were suffering from acute diarrhea with severe dehydration. Total 105 infants were selected and randomly divided into three groups having 35 infants in each group. Infants in group A received standard treatment of diarrhea. Infants in group B and C received Enterococcus faecium SF68 and Saccharomyces boulardii respectively twice daily for five days along with standard treatment of diarrhea. All the infants were monitored for five days. The treatment response was observed in terms of frequency of diarrhea, duration of diarrhea, stool consistency and length of hospital stay. Results: The frequency of diarrhea, duration of diarrhea and length of hospital stay were significantly reduced in both group B and C as compared to group A. Conclusion: Enterococcus faecium SF68 and Saccharomyces boulardii helped to reduce the stool frequency, duration of diarrhea, length of hospital stay and also improved the stool consistency in acute severe diarrhea in infants.

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屎肠球菌SF68和博氏酵母菌对婴幼儿急性严重腹泻的保护作用:随机对照试验

目的:观察屎肠球菌SF68和博氏酵母菌在婴幼儿急性重症腹泻中的作用。方法:在拉合尔儿童医院进行单盲、随机对照临床试验。这些婴儿的年龄在6个月到12个月之间。所有婴儿都患有严重脱水的急性腹泻。105名婴儿被随机分为三组，每组35名婴儿。A组患儿接受腹泻标准治疗。B组和C组婴儿分别给予粪肠球菌SF68和博氏酵母菌，每日2次，连续5天，并给予腹泻标准治疗。所有的婴儿都被监测了5天。从腹泻频率、腹泻持续时间、粪便稠度和住院时间等方面观察治疗效果。结果:与a组相比，B组和C组患儿腹泻次数、腹泻持续时间和住院时间均明显减少。结论:粪肠球菌SF68和博氏酵母菌对婴幼儿急性重症腹泻患儿的大便次数、腹泻持续时间、住院时间均有降低作用，并改善大便一致性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Esculapio

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审稿时长

12 weeks