Devil or angel: two roles of carbon monoxide in stroke

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Gas Research Pub Date : 2022-04-17 DOI:10.4103/2045-9912.337993

Bing Li, Jian Xiong, Huijiang Liu, Di Li, Gang Chen

引用次数: 7

Abstract

Stroke is one of the most important acute diseases that endanger human health and result in death, including acute cerebral hemorrhage and acute cerebral ischemia. Acute onset is its most prominent feature. Carbon monoxide (CO) is a colorless and odorless gas existing at room temperature. It is not only a common air pollutant, but also has been found to be closely related to stroke. A large amount of exogenous CO has an important impact on the incidence and prognosis of stroke, while endogenous CO as a gas signal also has an important impact on neuroprotection after stroke. Both low-dose CO inhalation and CO-releasing molecule-3 (a molecule that emits CO) treatment have shown the benefits of stroke, and perhaps the role of CO in stroke is one of the key areas for future research.

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魔鬼或天使:一氧化碳在中风中的两种作用

脑卒中是危害人类健康和导致死亡的最重要的急性疾病之一，包括急性脑出血和急性脑缺血。急性发作是其最突出的特点。一氧化碳(CO)是一种在室温下存在的无色无味的气体。它不仅是一种常见的空气污染物，而且已被发现与中风密切相关。大量外源性CO对脑卒中的发生和预后有重要影响，同时内源性CO作为一种气体信号对脑卒中后的神经保护也有重要影响。低剂量CO吸入和CO释放分子-3(一种释放CO的分子)治疗均显示出卒中的益处，CO在卒中中的作用可能是未来研究的重点领域之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.10

自引率

13.80%

发文量

期刊介绍： Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.