Novel Recombinant Rabbit Hemorrhagic Disease Virus 2 (RHDV2) is Circulating in China within 12 Months after Original RHDV2 Arrival

IF 3.5 2区 农林科学 Q2 INFECTIOUS DISEASES
Bo Hu, Z. Fan, R. Qiu, Mengmeng Chen, Houjun Wei, Yanhua Song, Weilong Liu, Weizhong Xu, Fang Wang
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Abstract

Rabbit hemorrhagic disease (RHD) causes lethal fulminant hepatitis in rabbits. Two different genotypes (GI.1 and GI.2) responsible for RHD are reported. GI.2 was first detected in France in 2010 and subsequently spread to other countries in Europe. In April 2020, GI.2 was detected in China. In this study, we report a novel recombinant strain of fatal rabbit hemorrhagic disease virus 2 (RHDV2 or GI.2) detected from domestic rabbits in three provinces in China in 2020–2021. Full-length genomic analysis has revealed that the recombinant virus contained an RHDV2 capsid gene and nonstructural genes from an unclassified lagovirus genotype. This type of virus emerged and circulated throughout China within a year after the initial detection of the original RHDV2. Compared with the original strain, the new virus showed a longer infected time and lower mortality rate but almost the same viral load at the moribund stage of infection. This might have resulted in high virus contamination in the environment, facilitating virus transmission. As the consequences of the presence of novel recombinant strains are unpredictable, the circulation of the novel variant in the population should be carefully monitored in China.
新型重组兔出血性疾病病毒2 (RHDV2)在原RHDV2到达后的12个月内在中国流行
兔出血性疾病(RHD)引起家兔致死性暴发性肝炎。两种不同的基因型(GI.1和GI.2)负责RHD的报道。gi - 2于2010年首次在法国被发现,随后传播到欧洲其他国家。2020年4月,中国检测到GI.2。在这项研究中,我们报告了2020-2021年在中国三个省的家兔中检测到的一种新的重组兔致死性出血症病毒2 (RHDV2或GI.2)株。全长基因组分析显示,重组病毒含有一个RHDV2衣壳基因和来自一个未分类lagovirus基因型的非结构基因。这种类型的病毒在最初检测到原RHDV2后的一年内出现并在中国各地传播。与原株相比,新病毒感染时间更长,死亡率更低,但在感染垂死阶段病毒载量几乎相同。这可能导致环境中的病毒高度污染,从而促进病毒传播。由于新型重组菌株存在的后果是不可预测的,因此在中国应仔细监测新型变异在人群中的传播。
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来源期刊
Transboundary and Emerging Diseases
Transboundary and Emerging Diseases 农林科学-传染病学
CiteScore
8.90
自引率
9.30%
发文量
350
审稿时长
1 months
期刊介绍: Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions): Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread. Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope. Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies. Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies). Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.
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