Essential elements as critical players against SARS-CoV-2 activity

Q4 Biochemistry, Genetics and Molecular Biology

Journal of Integrated OMICS Pub Date : 2022-12-31 DOI:10.5584/jiomics.v12i2.216

J. D. de Jesus

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引用次数: 0

Abstract

Background: SARS-CoV-2 virus is currently one of the main causes of death worldwide. Several studies have suggested that various trace elements play a vital role in the immune activity during viral infection, being an important tool to understand the SARS-CoV-2 infection and its systemic behavior, which affects different organs. Purpose: To summarize recent studies that report the effect of trace elements on the immune system and their role in fighting SARS-CoV-2 infection, presenting potential biochemical routes. Method: The main databases (ScienceDirect®, Scopus®, PubMed®) were consulted to search for works published up to October 2022, focusing on the role of trace elements in the immune activity against viral infection, including SARS-CoV-2. Conclusion: Many elements can act both in the activation of the host’s immune activity and in the survival of the virus since these processes occur with the participation of essential metals to guarantee the integrity of their functions. However, the relationship between trace elements and viral infection is complex, and requires further studies, mainly, focusing on the systemic behavior of SARS-CoV-2 infection.

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关键要素是对抗SARS-CoV-2活性的关键因素

背景：严重急性呼吸系统综合征冠状病毒2型是目前全球死亡的主要原因之一。几项研究表明，各种微量元素在病毒感染期间的免疫活动中发挥着至关重要的作用，是了解严重急性呼吸系统综合征冠状病毒2型感染及其影响不同器官的系统行为的重要工具。目的：总结最近关于微量元素对免疫系统的影响及其在对抗严重急性呼吸系统综合征冠状病毒2型感染中的作用的研究，提出潜在的生化途径。方法：查阅主要数据库（ScienceDirect®、Scopus®、PubMed®），搜索截至2022年10月发表的作品，重点关注微量元素在对抗病毒感染（包括严重急性呼吸系统综合征冠状病毒2型）的免疫活性中的作用。结论：许多元素既可以激活宿主的免疫活性，也可以参与病毒的存活，因为这些过程是在必需金属的参与下发生的，以确保其功能的完整性。然而，微量元素与病毒感染之间的关系很复杂，需要进一步研究，主要集中在严重急性呼吸系统综合征冠状病毒2型感染的系统行为上。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Integrated OMICS Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： JIOMICS provides a forum for the publication of original research papers, letters to the editor, short communications, and critical reviews in all branches of pure and applied –omics subjects, such as proteomics, metabolomics, metallomics and genomics. Especial interest is given to papers where more than one –omics subject is covered. Papers are evaluated based on scientific novelty and demonstrated scientific applicability. Original research papers on fundamental studies, and novel sensor and instrumentation development, are especially encouraged. Novel or improved findings in areas such as clinical, medicinal, biological, environmental and materials –omics are welcome.