Recombinant Interferon α-2B Gel Combined with Lactobacillus as a Vaginal Capsule in Patients with Cervical High-Risk Human Papillomavirus

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2022-10-26 DOI:10.37290/ctnr2641-452x.21:47-52

Lin Kong, Jie Kong, Zhihong Chai, Guo‐Xian Tao, Xianli Cai, Lingxiao Ying, Jinmei Shi

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引用次数: 0

Abstract

This study was performed to investigate the effects of Lactobacillus vaginal capsules combined with recombinant human interferon α-2b gel on clinical efficacy, vaginal microbial function indicators, vaginal microecological balance, inflammation levels, and drug safety in patients with persistent cervical high-risk human papillomavirus infection. Patients with human papillomavirus infection (n = 128) were randomly divided into control and observation groups of equal size. Patients in the control group were treated with recombinant human interferon α-2b gel alone. Patients in the observation group were treated with Lactobacillus vaginal capsules and human interferon α-2b gel. After treatment, the clinical efficiency, microbial function index, and human papillomavirus-DNA conversion rate of patients in the observation group were significantly higher than those in the control group. Further, pH, Nugent scores, human papillomavirus-DNA viral load, vaginal microecological dysregulation rate, and inflammation level were significantly lower than those in the control group. Lactobacillus vaginal capsules in combination with recombinant human interferon α-2b gel improved clinical outcomes and disease regression rates in patients with human papillomavirus infection, while also improving vaginal microecological balance and suppressing inflammatory responses.

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重组干扰素α-2B凝胶联合乳酸杆菌阴道胶囊治疗宫颈高危型人乳头瘤病毒

本研究旨在研究乳酸杆菌阴道胶囊联合重组人干扰素α-2b凝胶对持续性宫颈高危型人乳头瘤病毒感染患者的临床疗效、阴道微生物功能指标、阴道微生态平衡、炎症水平和药物安全性的影响。人乳头瘤病毒感染患者（n=128）被随机分为大小相等的对照组和观察组。对照组患者单独使用重组人干扰素α-2b凝胶治疗。观察组采用乳酸杆菌阴道胶囊和人干扰素α-2b凝胶治疗。治疗后，观察组患者的临床疗效、微生物功能指数、人乳头瘤病毒DNA转化率均显著高于对照组。此外，pH、Nugent评分、人乳头瘤病毒DNA病毒载量、阴道微生态失调率和炎症水平均显著低于对照组。乳酸杆菌阴道胶囊与重组人干扰素α-2b凝胶联合使用，改善了人乳头瘤病毒感染患者的临床结果和疾病消退率，同时也改善了阴道微生态平衡，抑制了炎症反应。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.