Electrospun Morinda citrifolia Extract-Loaded Wound Dressings Promote Diabetic Wound Healing Through Antiinflammatory and Antioxidative Activities

Abstract

In the current study, Morinda citrifolia extract was loaded into gelatin-based electrospun scaffolds to treat diabetic wounds. The produced scaffolds were characterized in vitro using electron microscopy, cell culture studies, antimicrobial assessment, tensile strength assay, and water uptake capacity measurements. Wound healing function of these dressings was evaluated in a rat model of diabetic wound. Study showed that Morinda citrifolia extract-loaded wound dressings promoted diabetic wound healing by increasing wound size reduction rate and collagen deposition.