The lack of association between different LDL-C levels and oxidized LDL in patients with type 2 diabetes

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2023-07-06 DOI:10.1002/cdt3.84

Soghra Rabizadeh, Seyed Arsalan Seyedi, Seyed Ali Nabipoorashrafi, Maryamossadat Omidvar Siahkalmahalleh, Amirhossein Yadegar, Fatemeh Mohammadi, Armin Rajab, Alireza Esteghamati, Manouchehr Nakhjavani

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引用次数: 0

Abstract

Background

High concentrations of low-density lipoprotein cholesterol (LDL-C) have been a known risk factor for cardiovascular diseases. Also, the role of oxidized LDL (ox-LDL) in forming atherosclerosis plaque has been proven. However, it has not yet been proven that atherogenic LDL-C by-products like ox-LDL will decrease by keeping the LDL levels at the desired level. This study aimed to examine the relationship between LDL-C and ox-LDL in different LDL-C values in patients with type 2 diabetes (T2D).

Methods

In this cross-sectional study, 347 patients with T2D who received statins were enrolled. LDL-C values were defined into four groups as LDL-C < 55 mg/dL, 55 mg/dL ≤ to <70 mg/dL, 70 mg/dL ≤ to <100 mg/dL and LDL-C ≥ 100 mg/dL. Total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and ox-LDL were studied in the four defined groups.

Results

Ox-LDL levels were not different among the four groups (p = 0.30). In addition, LDL-C and ox-LDL levels had no significant correlation (r = 0.480, p = 0.376). Additionally, based on this study analysis, ox-LDL levels were significantly correlated with TG levels (r = 0.119, p < 0.05) and TG/HDL ratio (r = 0.390, p < 0.01).

Conclusions

It is concluded that ox-LDL levels were not associated with different LDL-C level categories from <55 mg/dL to >100 mg/dL in patients with T2D. However, the revealed association of ox-LDL with TG level and TG/HDL ratio may be considered in the clinic.

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2型糖尿病患者不同LDL - C水平与氧化LDL之间缺乏相关性

背景：高浓度低密度脂蛋白胆固醇（LDL-C）是心血管疾病的一个已知危险因素。此外，氧化型低密度脂蛋白（ox-LDL）在动脉粥样硬化斑块形成中的作用也已得到证实。然而，尚未证明引起动脉粥样硬化的LDL-C副产物（如ox-LDL）会通过将LDL水平保持在所需水平而降低。本研究旨在探讨2型糖尿病（T2D）患者不同LDL-C值下LDL-C和ox-LDL之间的关系。方法：在这项横断面研究中，347名接受他汀类药物治疗的T2D患者被纳入研究。LDL-C值分为四组，分别为LDL-C 结果：四组间Ox-LDL水平差异无统计学意义（p = 此外，LDL-C和ox-LDL水平无显著相关性（r = 0.480，p = 0.376）。此外，根据本研究分析，ox-LDL水平与TG水平显著相关（r = 0.119，p r = 0.390，p 结论：ox-LDL水平与100 mg/dL。然而，ox-LDL与TG水平和TG/HDL比率的相关性可能在临床上被考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.