Incidence and prevalence of diabetic retinopathy in the Greenlandic Inuit: A register-based study

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-10-01 DOI:10.1016/j.deman.2022.100108

Trine Jul Larsen , Marit Eika Jørgensen , Michael Lynge Pedersen , Henrik Lund-Andersen , Stine Byberg

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引用次数: 0

Abstract

Aims

Assess the incidence and prevalence of diabetic retinopathy (DR) among all persons registered with diabetes in the electronic medical records (EMR) from 2016 to 2020 and investigate factors associated with both incident and prevalent DR.

Methods

We calculated the five-year incidence rate of DR per 1000 person years, and calculated the prevalence of DR, using Poisson regression analysis. We calculated the incidence rate ratios (IRR) in univariate and multivariate Poisson regression analysis, to assess risk factors associated with incident DR. We calculated the Odds ratios (OR) to assess risk factors of prevalent DR in univariate and multivariate Logistic regression analyses.

Results

We found 10.4% persons developed incident DR during follow-up, equivalent to an incidence rate of DR of 29.2 pr. 1000 (95%CI: 22.9–37.3) person years. The total prevalence of DR was 13.6%. Higher HbA₁c levels and longer diabetes duration were significantly associated with incident and prevalent DR. Higher levels of LDL cholesterol were significantly associated with a lower risk of incident DR.

Conclusion

The incidence and prevalence of DR in Greenland is lower than in most other parts of the world. In agreement with previous studies on risk factors for DR, HbA₁c levels and diabetes duration were associated with incident/prevalent DR.

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格陵兰因纽特人糖尿病视网膜病变的发病率和患病率:一项基于登记的研究

目的评估2016 - 2020年电子病历(EMR)中登记的所有糖尿病患者的糖尿病视网膜病变(DR)的发病率和患病率，探讨与DR发病率和患病率相关的因素。方法计算每1000人年5年DR的发病率，并采用泊松回归分析计算DR的患病率。在单因素和多因素泊松回归分析中，我们计算了发病率比(IRR)，以评估与DR事件相关的危险因素。在单因素和多因素Logistic回归分析中，我们计算了比值比(OR)，以评估流行DR的危险因素。我们发现10.4%的人在随访期间发生了偶发性DR，相当于DR的发病率为29.2 pr. 1000 (95%CI: 22.9-37.3)人年。DR总患病率为13.6%。较高的HbA1c水平和较长的糖尿病病程与DR的发生率和流行程度显著相关。较高的LDL胆固醇水平与DR发生的风险显著相关。结论格陵兰岛DR的发病率和流行程度低于世界上大多数其他地区。与之前关于DR危险因素的研究一致，HbA1c水平和糖尿病病程与DR的发生/流行相关。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.