Transition Metal-Catalyzed Remote C–H Bond Functionalization of Cyclic Amines

Abstract

C–H bond functionalization is one of the most effective strategies for the rapid synthesis of cyclic amines containing substituents in the ring, which are core structures of many bioactive molecules. It is, however, much more challenging to perform this strategy on remote C–H bonds compared to α-C–H bonds of cyclic amines. This graphical review aims to provide a concise overview on transition metal-catalyzed methods for the remote C–H bond functionalization of cyclic amines. Examples are categorized and demonstrated according to mechanistic pathways that initiate the reaction of cyclic amine substrates. Selected substrate scope and detailed reaction mechanisms are given when necessary.