The Nephroprotective Effect of Clove Oil (Oleum Caryophylli) Against Levofloxacin Toxicity in Rats

Q4 Pharmacology, Toxicology and Pharmaceutics

Iranian Journal of Toxicology Pub Date : 2022-01-01 DOI:10.32598/ijt.16.1.854.1

Anitsah Fiqardina, Yulia Yusrini Djabir, A. Santoso, Syafira Nurul Salsabil, I. Ismail

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引用次数: 1

Abstract

Background: Levofloxacin is a fluoroquinolone antibiotic that has broad-spectrum antimicrobial activity, but it may induce kidney dysfunction. Clove oil (Oleum caryophylli) has antioxidant properties that may alleviate levofloxacin toxicity. This study aimed to examine the protective effect of clove oil on levofloxacin-induced nephrotoxicity in rat animal models. Methods: A total of 24 male rats were divided into 6 groups. One group did not receive levofloxacin to serve as the control. The treatment groups received a single daily administration of levofloxacin (93 mg/kg) with either placebo or clove oil (10 mg/kg, 25 mg/kg, or 50 mg/kg per body weight) pre-treatment. Another group received Curcuma extract pre-treatment as a comparison. Blood samples were withdrawn after 28 days of treatment to measure serum biomarkers (urea and creatinine), and the kidneys were removed to measure renal Malondialdehyde (MDA) and histopathological analysis. Results: The results showed that clove oil pre-treatment at a dose of 10 mg/kg was able to reduce renal MDA and serum biomarker levels (P<0.05). The effect was similar to that found in Curcuma-treated rats. In addition, clove oil (10 mg/kg) was also found to ameliorate renal histopathological damage due to levofloxacin. Conclusion: Based on biomarker and histopathological analysis, clove oil pre-treatment in rats provides a nephroprotective effect against levofloxacin toxicity.

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丁香油对左氧氟沙星大鼠肾脏毒性的保护作用

背景：左氧氟沙星是一种具有广谱抗菌活性的氟喹诺酮类抗生素，但可能引起肾功能紊乱。丁香油具有抗氧化特性，可以减轻左氧氟沙星的毒性。本研究旨在观察丁香油对左氧氟沙星所致大鼠肾毒性的保护作用。方法：将24只雄性大鼠随机分为6组。一组不接受左氧氟沙星作为对照。治疗组接受左氧氟沙星（93 mg/kg）的单次每日给药，安慰剂或丁香油（10 mg/kg、25 mg/kg或50 mg/kg/体重）预处理。另一组接受姜黄提取物预处理作为比较。治疗28天后抽取血样，测量血清生物标志物（尿素和肌酐），取肾测量肾脏丙二醛（MDA）和组织病理学分析。结果：丁香油10 mg/kg预处理能显著降低大鼠肾脏MDA和血清生物标志物水平（P＜0.05），其作用与姜黄治疗组相似。此外，丁香油（10mg/kg）也被发现可以改善左氧氟沙星引起的肾脏组织病理学损伤。结论：根据生物标志物和组织病理学分析，丁香油预处理对左氧氟沙星毒性大鼠具有肾保护作用。

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