Study of liver X receptor-alpha gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients

IF 0.3 Q4 DERMATOLOGY

Journal of the Egyptian Women's Dermatologic Society Pub Date : 2022-05-01 DOI:10.4103/jewd.jewd_68_21

Alsayeda A A Taha, N. Mohamed, Eman Alsayed, Amany Gamal Ahmed

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引用次数: 0

Abstract

Background Vitiligo is an acquired skin disorder that results from selective destruction of skin melanocytes. It is characterized clinically by the development of depigmented macules and patches. More than 150 genes have been identified to affect the pigmentation of the skin, hair, and eyes. Liver X receptor-α (LXR-α) expression is upregulated in the melanocytes of the perilesional skin as compared with the normal skin of vitiligo patients suggesting its possible contribution in vitiligo pathogenesis. Objective To study LXR-α gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients. Patients and methods This case–control study was conducted on 25 vitiligo patients aged from 12 to 50 years compared with 25 age- and sex-matched controls. LXR-α gene polymorphism (rs2279238) (C>T) detection was done by allelic discrimination using fluorogenic 5’ Nuclease assay. Results LXR-α gene polymorphism was significantly associated with vitiligo among Egyptian patients but is not correlated with either severity or activity of vitiligo. Conclusion LXR-α gene polymorphism may be associated with vitiligo as found in a sample of Egyptian patients.

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埃及白癜风患者肝脏X受体α基因多态性(rs2279238)的研究

背景白癜风是一种获得性皮肤病，由皮肤黑素细胞的选择性破坏引起。其临床特征是出现色素沉着的黄斑和斑块。已经确定了150多个影响皮肤、头发和眼睛色素沉着的基因。与白癜风患者的正常皮肤相比，肝X受体-α（LXR-α）在病变周围皮肤的黑色素细胞中的表达上调，这表明其可能参与了白癜风的发病机制。目的研究埃及白癜风患者LXR-α基因多态性（rs2279238）。患者和方法本病例对照研究对25名年龄在12至50岁的白癜风患者进行了研究，并与25名年龄和性别匹配的对照组进行了比较。用荧光5′核酸酶法检测LXR-α基因多态性（rs2279238）（C>T）。结果LXR-α基因多态性与埃及患者的白癜风有显著相关性，但与白癜风的严重程度或活动性无关。结论LXR-α基因多态性可能与埃及白癜风患者有关。

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来源期刊

Journal of the Egyptian Women's Dermatologic Society Medicine-Dermatology

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： The Journal of The Egyptian Women''s Dermatologic Society (JEWDS) was founded by Professor Zenab M.G. El-Gothamy. JEWDS is published three times per year in January, May and September. Original articles, case reports, correspondence and review articles submitted for publication must be original and must not have been published previously or considered for publication elsewhere. Their subject should pertain to dermatology or a related scientific and technical subject within the field of dermatology.