Efficacy and safety of corpus callosotomy versus vagus nerve stimulation as long-term adjunctive therapies in children with Lennox–Gastaut syndrome

IF 1.2 4区医学 Q4 CLINICAL NEUROLOGY

Neurosciences Pub Date : 2022-04-01 DOI:10.17712/nsj.2022.2.20210135

Ghalib M. Alanazi, Turki F. AlOsaimi, A. Alwadei, Ali Al-Otaibi, Lamya A. Jad, A. Al-Attas

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引用次数: 1

Abstract

Objectives: To compare the efficacy and safety of corpus callosotomy versus vagus nerve stimulation (VNS) as long-term adjunctive therapies in children with Lennox–Gastaut syndrome. Methods: This retrospective study was conducted in King Fahad Medical City between 2010 and 2019. The authors identified and followed 9 patients with Lennox–Gastaut syndrome (LGS) who underwent corpus callosotomy or VNS implantation for at least 12 months; seizure frequency and major complications were monitored. Five patients with a mean age of 10.8±1.3 years had corpus callosotomy, and 4 patients with a mean age of 13.8±3.9 years were implanted with VNS stimulators. Results: Reduction in seizure frequency was achieved in all 5 patients who underwent corpus callosotomy, with greater than 75% seizure reduction in more than 50% in one, and greater than 25% in 2 respectively. However, in those implanted with VNS, 2 (50%) patients achieved a reduction in seizure frequency of greater than 75% and 2 (50%) greater than 25%, respectively. No significant difference was observed between the 2 treatment groups. One patient who underwent corpus callosotomy suffered cerebrospinal fluid leakage, and swallowing difficulties in one patient who underwent VNS. Conclusion: Both corpus callosotomy and VNS are safe and effective as adjunctive treatments for LGS patients.

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胼胝体切开术与迷走神经刺激作为lenox - gastaut综合征儿童长期辅助治疗的疗效和安全性

目的:比较胼胝体切开术与迷走神经刺激(VNS)作为lenox - gastaut综合征儿童长期辅助治疗的疗效和安全性。方法:2010 - 2019年在法赫德国王医疗城进行回顾性研究。作者确定并随访了9例lenox - gastaut综合征(LGS)患者，他们接受了胼胝体切开术或VNS植入至少12个月;监测癫痫发作频率及主要并发症。5例患者(平均年龄10.8±1.3岁)行胼胝体切开术，4例患者(平均年龄13.8±3.9岁)植入VNS刺激器。结果:5例行胼胝体切开术的患者癫痫发作频率均降低，其中1例癫痫发作率降低75%以上，50%以上，2例癫痫发作率降低25%以上。然而，在植入VNS的患者中，2例(50%)患者癫痫发作频率降低超过75%，2例(50%)患者癫痫发作频率降低超过25%。两组间差异无统计学意义。1例行胼胝体切开术的患者出现脑脊液漏，1例行VNS的患者出现吞咽困难。结论:胼胝体切开术和VNS作为LGS患者的辅助治疗是安全有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurosciences 医学-临床神经学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4.5 months

期刊介绍： Neurosciences is an open access, peer-reviewed, quarterly publication. Authors are invited to submit for publication articles reporting original work related to the nervous system, e.g., neurology, neurophysiology, neuroradiology, neurosurgery, neurorehabilitation, neurooncology, neuropsychiatry, and neurogenetics, etc. Basic research withclear clinical implications will also be considered. Review articles of current interest and high standard are welcomed for consideration. Prospective workshould not be backdated. There are also sections for Case Reports, Brief Communication, Correspondence, and medical news items. To promote continuous education, training, and learning, we include Clinical Images and MCQ’s. Highlights of international and regional meetings of interest, and specialized supplements will also be considered. All submissions must conform to the Uniform Requirements.