The STAT4 SNP (rs7574865) and systemic lupus erythematosus

IF 1.1 Q4 IMMUNOLOGY
G. Bayat, S. M. Hejazian, E. Ahmadian, Seyed Sina Hejazian, A. Khabbazi, S. Zununi Vahed, M. Ardalan
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引用次数: 0

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease affecting several systems and organs in the body. The association of STAT4 transcription factor with SLE risk remains unclear. Objectives: The aim of this study was to investigate the association of STAT4 gene polymorphism (rs7574865) with the incidence of SLE. Patients and Methods: One hundred and sixty participants (80 patients with SLE and 80 healthy individuals) were included in this study. Gene analysis was conducted by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) in peripheral blood samples. Results: Fifty-seven percent (n=45) of patients with SLE had SLE disease activity index (SLEDAI) above six and had active disease. In the SLE group, the frequency of G and T alleles were 81% and 19%, respectively. Moreover, 72.50% (n=58) of patients carried the GG genotype, 17.5% (n=14) had the GT genotype and 10.1% (n=8) carried the TT genotype. There was no significant difference between allele frequency and genotypic distribution for rs7574865 polymorphism (P>0.05) between SLE and control groups. Significant differences were observed between the distribution of genotypes and clinical manifestations including leukopenia (P=0.04), pulmonary (P=0.01) and ophthalmic (P=0.049) problems. The T allele with an odd ratio of 1.47 and confidence interval of 0.80 to 2.6 could increase the risk of SLE; however, it was not statistically significant (P=0.20). Conclusion: The T allele and TT genotype of the STAT4 rs7574865 polymorphism could increase the risk of lupus; however, these observations were not statistically significant.
STAT4 SNP (rs7574865)与系统性红斑狼疮的关系
系统性红斑狼疮(SLE)是一种影响身体多个系统和器官的异质自身免疫性疾病。STAT4转录因子与SLE风险的关系尚不清楚。目的:本研究的目的是探讨STAT4基因多态性(rs7574865)与SLE发病率的关系。患者和方法:160名参与者(80名SLE患者和80名健康个体)纳入本研究。采用扩增难解突变系统-聚合酶链反应(ARMS-PCR)对外周血标本进行基因分析。结果:57% (n=45)的SLE患者SLE疾病活动指数(SLEDAI)大于6,为活动性疾病。在SLE组中,G和T等位基因的频率分别为81%和19%。GG基因型患者占72.50% (n=58), GT基因型患者占17.5% (n=14), TT基因型患者占10.1% (n=8)。SLE组与对照组rs7574865多态性等位基因频率及基因型分布差异无统计学意义(P < 0.05)。基因型分布与白细胞减少(P=0.04)、肺部问题(P=0.01)、眼部问题(P=0.049)的临床表现差异有统计学意义。T等位基因的奇比为1.47,置信区间为0.80 ~ 2.6,可增加SLE的发病风险;但差异无统计学意义(P=0.20)。结论:STAT4 rs7574865多态性的T等位基因和TT基因型可增加狼疮的发病风险;然而,这些观察结果没有统计学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
发文量
65
审稿时长
3 weeks
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