Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation

IF 0.3 Q4 CHEMISTRY, MULTIDISCIPLINARY

Oriental Journal Of Chemistry Pub Date : 2023-08-30 DOI:10.13005/ojc/390401

Weiam A. Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, W. M. A. Khojali, N. Khalifa, Farhan Alshammari, Tahani S. Albalawi, Ghaliah Alshammary, Zhawah F. Alshammary, Haya O. Almutairi, Reem M. Alrasheedi, Shahad Fayad

{"title":"Correlation Between Structure and New Anti-cancer Activity of Some Antioxidants Following Chemical Structure Modification Does The Evidence Support This Correlation","authors":"Weiam A. Hussein, Mohammed Khaled Bin Break, A. Alafnan, Bader I Huwaimel, W. M. A. Khojali, N. Khalifa, Farhan Alshammari, Tahani S. Albalawi, Ghaliah Alshammary, Zhawah F. Alshammary, Haya O. Almutairi, Reem M. Alrasheedi, Shahad Fayad","doi":"10.13005/ojc/390401","DOIUrl":null,"url":null,"abstract":"In medicinal chemistry, the link between structure and activity is essential. We are seeking to relate chemical structure and reactivity to medicinal properties, which has gained popularity recently. In this study, scaffolds from three antioxidants were changed to new derivatives to show that their biological effects as antioxidants would change. We also reviewed the anticancer effects of these medications (based on the SRB test) to find other biological effects that may be related to their chemical structural modifications. Moreover, SWISS ADME software was used to determine further ADME characteristics. Compound 2C had the highest cytotoxicity (1.2 μM) against lung cancer cell lines, whereas 1C had good cytotoxicity (87.66 μM). Compound 2C also demonstrated excellent cytotoxicity against the other three cell lines with IC50 values of 5.049, 6.26, and 9.71 μM, respectively. After its antioxidant structure was tweaked, 1C might be a critical molecule for building a novel treatment for lung cancer.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":" ","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oriental Journal Of Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.13005/ojc/390401","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

In medicinal chemistry, the link between structure and activity is essential. We are seeking to relate chemical structure and reactivity to medicinal properties, which has gained popularity recently. In this study, scaffolds from three antioxidants were changed to new derivatives to show that their biological effects as antioxidants would change. We also reviewed the anticancer effects of these medications (based on the SRB test) to find other biological effects that may be related to their chemical structural modifications. Moreover, SWISS ADME software was used to determine further ADME characteristics. Compound 2C had the highest cytotoxicity (1.2 μM) against lung cancer cell lines, whereas 1C had good cytotoxicity (87.66 μM). Compound 2C also demonstrated excellent cytotoxicity against the other three cell lines with IC50 values of 5.049, 6.26, and 9.71 μM, respectively. After its antioxidant structure was tweaked, 1C might be a critical molecule for building a novel treatment for lung cancer.

查看原文本刊更多论文

化学结构修饰后的抗氧化剂结构与新抗癌活性的相关性证明了这一相关性

在药物化学中，结构和活性之间的联系是必不可少的。我们正在寻求将化学结构和反应性与药物性质联系起来，这在最近得到了普及。本研究将三种抗氧化剂的支架改为新的衍生物，以表明它们作为抗氧化剂的生物学效应会发生变化。我们还回顾了这些药物的抗癌作用(基于SRB试验)，以发现可能与其化学结构修饰有关的其他生物学效应。此外，使用SWISS ADME软件确定进一步的ADME特征。化合物2C对肺癌细胞株的细胞毒性最高(1.2 μM)，而化合物1C对肺癌细胞株的细胞毒性较好(87.66 μM)。化合物2C对其他3种细胞系的IC50值分别为5.049、6.26和9.71 μM，具有良好的细胞毒性。在其抗氧化结构被调整后，1C可能成为构建肺癌新疗法的关键分子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oriental Journal Of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

自引率

20.00%

发文量

172

期刊介绍： Oriental Journal of Chemistry was started in 1985 with the aim to promote chemistry research. The journal consists of articles which are rigorously peer-reviewed. The journal was indexed in Emerging Science citation index in 2016. The Editorial board member consists of eminent international scientist in all fields of Chemistry. Details of each member and their contact information is mentioned in website. The journal has thorough ethics policies and uses plagiarism detection software(ithenticate) to screen each submission. The journal has recently partnered with publons as a part of making our reviews more transparent. The journal has recently incorporated PlumX for article level matrix. The journal is promoting research on all social and academic platforms mentioned in PlumX guidelines. The journal uses google maps to improve on the geographical distribution of Editorial board members as well as authors.