Immunobiology of Long Noncoding RNAs.

IF 26.9 1区医学 Q1 IMMUNOLOGY

Annual review of immunology Pub Date : 2017-04-26 DOI:10.1146/annurev-immunol-041015-055459

Maninjay K. Atianand, Daniel R. Caffrey, K. Fitzgerald

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引用次数: 349

Abstract

The discovery of long noncoding RNAs (lncRNA) has provided a new perspective on gene regulation in diverse biological contexts. lncRNAs are remarkably versatile molecules that interact with RNA, DNA, or proteins to promote or restrain the expression of protein-coding genes. Activation of immune cells is associated with dynamic changes in expression of genes, the products of which combat infectious microorganisms, initiate repair, and resolve inflammatory responses in cells and tissues. Recent evidence indicates that lncRNAs play important roles in directing the development of diverse immune cells and controlling the dynamic transcriptional programs that are a hallmark of immune cell activation. The importance of these molecules is underscored by their newly recognized roles in inflammatory diseases. In this review, we discuss the contribution of lncRNAs in the development and activation of immune cells and their roles in immune-related diseases. We also discuss challenges faced in identifying biological functions for this large and complex class of genes.

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长链非编码rna的免疫生物学。

长链非编码RNA（lncRNA）的发现为不同生物学背景下的基因调控提供了新的视角。lncRNA是一种非常通用的分子，与RNA、DNA或蛋白质相互作用，促进或抑制蛋白质编码基因的表达。免疫细胞的激活与基因表达的动态变化有关，基因的产物对抗感染性微生物，启动修复，并解决细胞和组织中的炎症反应。最近的证据表明，lncRNA在指导不同免疫细胞的发育和控制作为免疫细胞激活标志的动态转录程序方面发挥着重要作用。这些分子在炎症性疾病中的新作用突显了它们的重要性。在这篇综述中，我们讨论了lncRNA在免疫细胞发育和激活中的作用及其在免疫相关疾病中的作用。我们还讨论了在识别这类庞大而复杂的基因的生物学功能方面面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of immunology 医学-免疫学

CiteScore

57.20

自引率

0.70%

发文量

期刊介绍： The Annual Review of Immunology, in publication since 1983, focuses on basic immune mechanisms and molecular basis of immune diseases in humans. Topics include innate and adaptive immunity; immune cell development and differentiation; immune control of pathogens (viruses, bacteria, parasites) and cancer; and human immunodeficiency and autoimmune diseases. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.