Use of patent information to characterize trends in the therapeutic applications of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs).

Q3 Biochemistry, Genetics and Molecular Biology
Ángela Ponce-Polo, Alvaro RitoréHidalgo, Arturo Argüello Martínez, Roke Iñaki Oruezabal Guijarro
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引用次数: 0

Abstract

Extracellular vesicles derived from mesenchymal stromal cells (MSC-EVs) are gaining interest for medical purposes. The promising therapeutic effects exhibited in both preclinical and clinical studies suggest that they may become an alternative for certain applications to cell-based therapies, which are subjected to stricter regulations. The commercial exploitation of these candidates requires a proper patent strategy from both the industry and public research organizations. Here, we raise a global patent literature analysis to identify key players and therapeutic applications in the field. Our results show an increasing rate of patent publications since 2009, with Asia (specifically China) leading the patenting activity. The therapeutic use of MSC-EVs within patent literature covers a wide range of diseases, in which "Dermal and Wounds", "Neurology" and "Cardiovascular" are the main therapeutic areas. Moreover, most of these patents include "product-by-process" claims, since the therapeutic effects of MSC-EVs could be influenced by their manufacturing process. Our results follow scientific and clinical literature trends.
利用专利信息描述间充质干细胞(msc - ev)衍生的细胞外囊泡治疗应用的趋势。
来源于间充质基质细胞(msc - ev)的细胞外囊泡在医学上越来越受到关注。在临床前和临床研究中显示出的有希望的治疗效果表明,它们可能成为某些应用的替代细胞疗法,细胞疗法受到更严格的监管。这些候选药物的商业利用需要工业界和公共研究机构制定适当的专利战略。在这里,我们提出了一个全球专利文献分析,以确定在该领域的关键参与者和治疗应用。我们的研究结果显示,自2009年以来,专利发表率不断上升,亚洲(特别是中国)的专利活动处于领先地位。在专利文献中,msc - ev的治疗用途涵盖了广泛的疾病,其中“皮肤和伤口”、“神经病学”和“心血管”是主要的治疗领域。此外,由于msc - ev的治疗效果可能受到其制造工艺的影响,这些专利中的大多数包括“逐工艺产品”的权利要求。我们的结果遵循科学和临床文献的趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Recent patents on biotechnology
Recent patents on biotechnology Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
2.90
自引率
0.00%
发文量
51
期刊介绍: Recent Patents on Biotechnology publishes review articles by experts on recent patents on biotechnology. A selection of important and recent patents on biotechnology is also included in the journal. The journal is essential reading for all researchers involved in all fields of biotechnology.
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