HYPERLIPIDEMIA IS A DOMINANT RISK FACTOR FOR CORONARY HEART DISEASE

I. Adiputra, N. Trisnadewi, Nia Oktaviani, Dewa Putu Dwita
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引用次数: 1

Abstract

Background: Coronary heart disease (CHD) is a major health problem in developed and developing countries. Until now, the death rate due to CHD is the highest in the world. Its risk factors include major modifiable risk factors, such as hyperlipidemia, hypertension, diabetes mellitus, obesity, smoking, and non-modifiable risk factors. Purpose: This study aimed to determine the major risk factors for the incidence of CHD. Methods: This study employed an unmatched case-control design, with a total sample of 43 cases and 86 controls recruited by a purposive sampling technique. Case samples were CHD patients diagnosed by a cardiologist and control samples were non-CHD patients who visited the cardiac polyclinic, with similar variables of age, sex, and residence. The samples were taken at the integrated heart center of Sanglah Hospital, Denpasar, based on the patient medical records. Data analysis was performed using the Chi-square test and logistic regression. Results: The results showed three risk factors that statistically and significantly increased the incidence of CHD, namely history of total cholesterol of ≥240mg/dl with adjusted OR=4.64 (95% CI: 1.60-13.49), type-2 diabetes mellitus with adjusted OR=2.85 (95% CI: 1.16-6.99), and smoking with adjusted OR=2.54 (95% CI: 1.01-6.46). Conclusion: The history of high total cholesterol is statistically the most dominant risk factor for the incidence of CHD.
高脂血症是冠心病的主要危险因素
背景:冠心病是发达国家和发展中国家的主要健康问题。到目前为止,冠心病的死亡率是世界上最高的。其危险因素包括主要可改变的危险因素,如高脂血症、高血压、糖尿病、肥胖、吸烟和不可改变的风险因素。目的:本研究旨在确定冠心病发病的主要危险因素。方法:本研究采用了一种不匹配的病例对照设计,通过有目的的抽样技术招募了43例病例和86名对照者。病例样本为心脏病专家诊断的冠心病患者,对照样本为访问心脏综合诊所的非冠心病患者,年龄、性别和居住地的变量相似。这些样本是在登巴萨桑拉医院的综合心脏中心根据患者的医疗记录采集的。数据分析采用卡方检验和逻辑回归。结果:三个危险因素在统计学上显著增加了CHD的发生率,即总胆固醇≥240mg/dl并校正OR=4.64(95%CI:1.60-13.49)、2型糖尿病并校正OR=2.85(95%CI:1.16-6.99),吸烟校正OR=2.54(95%CI:1.01-6.46)。结论:高总胆固醇史是CHD发病率的最主要危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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