Plasma surfactant protein-D as a potential biomarker in idiopathic pulmonary fibrosis

IF 1 Q4 RESPIRATORY SYSTEM
M. E. El Nady, S. Kaddah, Yasmine Hamdy El Hinnawy, R. Halim, Reham Kandeel
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引用次数: 1

Abstract

Objectives Idiopathic pulmonary fibrosis (IPF) is a disease of an increasing burden. Its diagnosis is based on definite high-resolution computed tomography pattern and is associated with the histopathological and/or radiological pattern of usual interstitial pneumonia with exclusion of other causes of interstitial pneumonia. The surfactant protein-D (SP-D) level in the serum is measured in several lung diseases, including IPF. Aim of study The aim of the current study is to assess the serum level of SP-D as a potential biomarker to distinguish between IPF and other idiopathic interstitial pneumonia patients. Patients and methods This study was conducted in the Chest Department, Kasr Al Ainy Hospitals, Cairo University. The study population included 20 healthy controls, 20 IPF patients, and 18 other idiopathic interstitial pneumonia patients. All were subjected to full history taking, clinical examination, high-resolution computed tomography chest, spirometry, arterial blood gases, blood samples for measuring SP-D by enzyme-linked immunosorbent assay. Results There was no statistical significance between the serum level of SP-D in IPF and non-IPF patients, however, there was a significant increase in the serum level of SP-D in IPF patients diagnosed at a late stage compared with those diagnosed at an early stage and those on anti-fibrotic therapy. Also, there was a statistical significance between the degree of clubbing and gastroesophageal reflux disease and the serum level of SP-D with a P value of 0.005 and 0.029, respectively. Serum SP-D level had a negative correlation with more severe form of the disease regarding the duration of illness, forced vital capacity percent, and it had a significant negative correlation with oxygen saturation and 6 min walk distance with a P value of 0.023 and 0.005, respectively. Conclusion The level of serum SP-D level in IPF patients correlate well with the severity of the disease and could be a possible marker to use for the follow up of patients on anti-fibrotic drugs.
血浆表面活性蛋白d作为特发性肺纤维化的潜在生物标志物
特发性肺纤维化(IPF)是一种负担日益加重的疾病。其诊断基于明确的高分辨率计算机断层扫描模式,并与常规间质性肺炎的组织病理学和/或放射学模式相关,排除了间质性肺炎的其他原因。血清表面活性剂蛋白- d (SP-D)水平在几种肺部疾病,包括IPF测量。本研究的目的是评估血清SP-D水平作为区分IPF和其他特发性间质性肺炎患者的潜在生物标志物。患者和方法本研究在开罗大学Kasr Al Ainy医院胸科进行。研究人群包括20名健康对照者、20名IPF患者和18名其他特发性间质性肺炎患者。所有患者均接受了完整的病史记录、临床检查、高分辨率胸部计算机断层扫描、肺活量测定、动脉血气测定、血液样本酶联免疫吸附法测定SP-D。结果IPF患者与非IPF患者血清SP-D水平差异无统计学意义,但晚期IPF患者血清SP-D水平较早期诊断及抗纤维化治疗组明显升高。棍状和胃食管反流病的程度与血清SP-D水平的差异有统计学意义,P值分别为0.005和0.029。血清SP-D水平与病程、强迫肺活量百分比与病情严重程度呈负相关,与血氧饱和度、6 min步行距离呈显著负相关,P值分别为0.023、0.005。结论IPF患者血清SP-D水平与病情的严重程度有较好的相关性,可作为抗纤维化药物随访的指标之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Egyptian Journal of Bronchology
Egyptian Journal of Bronchology RESPIRATORY SYSTEM-
自引率
7.70%
发文量
56
审稿时长
9 weeks
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