Correction to: A process ontology approach in biochemistry: the case of GPCRs and biosignaling

IF 1.8 3区化学 Q1 HISTORY & PHILOSOPHY OF SCIENCE

Foundations of Chemistry Pub Date : 2023-01-20 DOI:10.1007/s10698-022-09461-8

Fiorela Alassia

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Abstract

According to process ontology in the philosophy of biology, the living world is better understood as processes rather than as substantial individuals. Within this perspective, an organism does not consist of a hierarchy of structures like a machine, but rather a dynamic hierarchy of processes, dynamically maintained and stabilized at different time scales. With this respect, two processual approaches on enzymes by Stein (Hyle Int J Philos Chem 10(4):5–22, 2004, Process Stud 34:62–80, 2005, Found Chem 8:3–29, 2006) and by Guttinger (Everything Flows: Towards a Processual Philosophy of Biology, Oxford University Press, Oxford, 2018) allows to think of macromolecules as relational and processual entities. In this work, I propose to extend their arguments to another case study within the biochemical domain, which is the case of ligand receptors and receptor-mediated biosignaling. The aim of this work is to analyze the case of G Protein-Coupled Receptors and biosignaling under the consideration of a processual ontology. I will defend that the processual ontology framework is adequate for the biochemical domain and that it allows accounting for the current biochemical knowledge related to the case study.

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生物化学中的过程本体方法:以gpcr和生物信号传导为例

根据生物学哲学中的过程本体论，生命世界最好被理解为过程，而不是实体个体。从这个角度来看，一个有机体不像机器那样由层次结构组成，而是一个动态的过程层次结构，在不同的时间尺度上动态地维持和稳定。在这方面，Stein (Hyle Int J Philos Chem 10(4):5 - 22,2004, Process Stud 34:62 - 80,2005, Found Chem 8:3 - 29,2006)和Guttinger (Everything Flows: Towards a Process Philosophy of Biology, Oxford University Press, Oxford, 2018)对酶的两种过程方法允许将大分子视为关系和过程实体。在这项工作中，我建议将他们的论点扩展到生物化学领域的另一个案例研究，即配体受体和受体介导的生物信号传导。这项工作的目的是分析的情况下，G蛋白偶联受体和生物信号的考虑过程本体。我将捍卫过程本体框架对于生化领域来说是足够的，并且它允许对与案例研究相关的当前生化知识进行核算。

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来源期刊

Foundations of Chemistry HISTORY & PHILOSOPHY OF SCIENCE-

自引率

22.20%

发文量

期刊介绍： Foundations of Chemistry is an international journal which seeks to provide an interdisciplinary forum where chemists, biochemists, philosophers, historians, educators and sociologists with an interest in foundational issues can discuss conceptual and fundamental issues which relate to the `central science'' of chemistry. Such issues include the autonomous role of chemistry between physics and biology and the question of the reduction of chemistry to quantum mechanics. The journal will publish peer-reviewed academic articles on a wide range of subdisciplines, among others: chemical models, chemical language, metaphors, and theoretical terms; chemical evolution and artificial self-replication; industrial application, environmental concern, and the social and ethical aspects of chemistry''s professionalism; the nature of modeling and the role of instrumentation in chemistry; institutional studies and the nature of explanation in the chemical sciences; theoretical chemistry, molecular structure and chaos; the issue of realism; molecular biology, bio-inorganic chemistry; historical studies on ancient chemistry, medieval chemistry and alchemy; philosophical and historical articles; and material of a didactic nature relating to all topics in the chemical sciences. Foundations of Chemistry plans to feature special issues devoted to particular themes, and will contain book reviews and discussion notes. Audience: chemists, biochemists, philosophers, historians, chemical educators, sociologists, and other scientists with an interest in the foundational issues of science.