A Green Synthesis and Antibacterial Activity of N-Arylsulfonylhydrazone Compounds

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0023

Qian Yang, Wang Hao, Ya-Yi He, Qian Zhang, Xiaojiao Yu, Y. Hua

引用次数: 6

Abstract

Abstract A green method has been developed for the synthesis of N-arylsulfonylhydrazones via a simple grindstone procedure. By grinding mixtures of benzensulfonyl hydrazides and a series of aryl aldehydes or ketones in the mortar using L-tyrosine as catalyst, 24 N-arylsulfonylhydrazones were synthesized in a few minutes with high yield. All compounds were screened for their antibacterial activities. Most of them exhibit some antibacterial activities especially for 3d, 3l and 3v showing high activity against Staphylococcus aureus and Escherichia coli.

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N-芳基磺酰腙类化合物的绿色合成及其抗菌活性

摘要建立了一种简单的磨刀石法合成n -芳基磺酰腙的绿色方法。以l -酪氨酸为催化剂，在砂浆中研磨苯磺酰肼和一系列芳基醛或酮的混合物，在几分钟内合成了24个n -芳基磺酰肼，收率高。对所有化合物进行抑菌活性筛选。其中大多数具有一定的抑菌活性，特别是对3d、3l和3v具有较高的抑菌活性，对金黄色葡萄球菌和大肠杆菌具有较高的抑菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.