Anti-diabetic activity of Iphiona aucheri leaf extract

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2020-10-09 DOI:10.3329/BJP.V15I4.44170

Muhammad Abdur Rehman Shah, R. Khan, Mushtaq Ahmed

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引用次数: 6

Abstract

The methanolic extract of Iphiona aucheri leaves and its n-hexane, chloroform and aqueous fractions were screened for phytochemicals, cytotoxic effects, total phenolic contents, antioxidant and anti-diabetic properties. The methanolic extract was assessed for its in vivo anti-diabetic effects. The results indicated the presence of alkaloid, protein and amino acids, carbohydrates, glycosides, flavonoids, and saponins along with the highest brine shrimp lethality (90.7 ± 1.8%), α-amylase inhibition (60.2%) and free radical scavenging properties. The diabetic control indicated a significant (p<0.05) decrease in weight and high-density lipoprotein and elevated level of blood glucose, bilirubin, creatinine, urea, triglyceride, low density lipoprotein, very low-density lipoprotein, transaminases, and alkaline phosphatase. All these changes were restored significantly (p<0.05) by treatment of diabetic rats with methanolic extract of I. aucheri. The results show the potential of I. aucheri as a source of therapeutic compounds against diabetic, hyperlipidemia and free radical associated disorders.

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山楂叶提取物的抗糖尿病活性

对红叶的甲醇提取物及其正己烷、氯仿和水相组分进行了植物化学成分、细胞毒作用、总酚含量、抗氧化和抗糖尿病性能的筛选。研究了乙醇提取物的体内抗糖尿病作用。结果表明，其中含有生物碱、蛋白质和氨基酸、碳水化合物、糖苷、黄酮类化合物和皂苷，具有最高的卤虾致死率(90.7±1.8%)、α-淀粉酶抑制率(60.2%)和自由基清除能力。糖尿病对照组体重、高密度脂蛋白显著下降(p<0.05)，血糖、胆红素、肌酐、尿素、甘油三酯、低密度脂蛋白、极低密度脂蛋白、转氨酶、碱性磷酸酶升高(p<0.05)。这些变化在给药后均明显恢复(p<0.05)。研究结果表明，aucheri作为治疗糖尿病、高脂血症和自由基相关疾病的化合物的潜在来源。

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.