Ameliorative Effect of Pongamia Pinnata on Histopathology of Vital Organs Involved in the Alloxan Induced Diabetic Rats

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2022-09-16 DOI:10.1080/10496475.2022.2116623

A. Morajkar, Bharatbhushan Sharma, Kiran R Kharat

引用次数: 0

Abstract

ABSTRACT The ameliorative effect of aqueous (PPAqExt) and alcohol (PPAlcExt) extracts of Pongamia pinnata on degenerative histopathological changes in diabetic rats were investigated. Rats were divided into six groups. 1. Control group (NC). 2. Diabetic control group (DC)3. PPAqExt (TD1) 4. PPAlcExt (TD2) 5. Standard Control group (SD) 6. Vehicle Control group (VC). Blood samples were collected for the detection of Glycosylated Hemoglobin (HbA1c) levels. The vital organs pancreas, liver, kidney, and testis were prepared for histopathological studies. Treatment with PPAlcExt produced a reduction in HbA1c levels (8.4%) compared to DC (13.63%). The histopathological microscopic examination of diabetic rats showed marked changes in all the vital organs ranging from mild to severe along with cell infiltration, degeneration, and necrosis. Treatment with both the extracts showed a reversal in structural and cellular integrity of the vital organs involved in the pathophysiology of diabetes mellitus.

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桄榔子对四氧嘧啶诱导的糖尿病大鼠重要脏器组织病理学的改善作用

摘要:研究了桄榔子水提液(PPAqExt)和醇提液(ppalext)对糖尿病大鼠退行性组织病理学改变的改善作用。大鼠被分为六组。1. 对照组(NC)。2. 糖尿病对照组(DC)PPAqExt (TD1)ppalext (TD2)标准对照组(SD)车辆控制组(VC)。采集血样检测糖化血红蛋白(HbA1c)水平。胰腺、肝脏、肾脏和睾丸等重要器官准备进行组织病理学研究。与DC(13.63%)相比，ppalext治疗的HbA1c水平降低了8.4%。糖尿病大鼠组织病理学镜检显示，糖尿病大鼠各重要脏器有轻到重的明显改变，细胞浸润、变性、坏死。用这两种提取物治疗显示了与糖尿病病理生理有关的重要器官的结构和细胞完整性的逆转。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.