Functional Assessment of Therapy Tools for Cancer Cachexia: A Review

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-04-18 DOI:10.37290/ctnr2641-452x.21:187-193

Lee Tang, John Jenn Yenn Lu, Sheau-Chung Tang

引用次数: 0

Abstract

Cachexia is a multifactorial and multi-organ condition that increases the mortality rate of patients with advanced cancer. Amelioration of cancer patients’ weight loss and inflammatory status are critical to the treatment’s success. Cachexia contains a significant drop in body weight and a rapid loss of lipoprotein, accompanied by an inflammatory state. In the late stage of cancer, anorexia and cachexia may occur at the same time, a condition called anorexia and cachexia syndrome. Keeping abreast of the patient’s inflammatory and nutritional status is of utmost importance for optimal treatment. This review explores the contribution of nutrient changes and the novel biomarker proteins in anorexia and cachexia syndrome. Functional assessment using anorexia and cachexia therapy assessment tools can monitor and provide early signals for anorexia and cachexia syndrome and suggest mechanism-based interventions to improve the status of cachexia with appropriate nutrients or drugs.

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癌症恶病质治疗工具的功能评价综述

恶病质是一种多因素、多器官的疾病，会增加晚期癌症患者的死亡率。癌症患者的体重减轻和炎症状况的改善是治疗成功的关键。恶病质包括体重的显著下降和脂蛋白的快速损失，并伴有炎症状态。在癌症晚期，厌食和恶病质可能同时发生，这种情况被称为厌食和恶病质综合征。及时了解患者的炎症和营养状况对最佳治疗至关重要。本文综述了营养变化和新的生物标志物蛋白在厌食症和恶病质综合征中的作用。使用厌食症和恶病质治疗评估工具进行功能评估可以监测并提供厌食症和恶病质综合征的早期信号，并建议基于机制的干预措施，通过适当的营养或药物来改善恶病质状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.