Short- and long-term follow-up results of daily 5-mg tadalafil as a treatment for erectile dysfunction and premature ejaculation

IF 1.3 Q3 UROLOGY & NEPHROLOGY

Arab Journal of Urology Pub Date : 2022-01-02 DOI:10.1080/2090598X.2021.2024695

Tarek Mohamed Gharib, I. Abdel-Al, A. Elatreisy, W. Kandeel, W. El-Shaer, Abdrabuh M. Abdrabuh, El- Sayed Mohamed Salih, A. Sebaey

{"title":"Short- and long-term follow-up results of daily 5-mg tadalafil as a treatment for erectile dysfunction and premature ejaculation","authors":"Tarek Mohamed Gharib, I. Abdel-Al, A. Elatreisy, W. Kandeel, W. El-Shaer, Abdrabuh M. Abdrabuh, El- Sayed Mohamed Salih, A. Sebaey","doi":"10.1080/2090598X.2021.2024695","DOIUrl":null,"url":null,"abstract":"ABSTRACT Objective To evaluate the safety and effectiveness of daily 5-mg tadalafil treatment for men who have erectile dysfunction (ED) and premature ejaculation (PE), and to assess the long-term follow-up for ED and PE improvement persistence years after the cessation of medication. Patients and Methods A prospective, single-blind, randomised study included 160 patients with ED and PE. All were evaluated using the International Index of Erectile Function (IIEF-5) questionnaire to evaluate ED and intravaginal ejaculatory latency time (IELT) for PE. Patients were subdivided into two equal groups. Group I (80 patients) treated with daily 5-mg tadalafil for 3 months, and Group II (80 patients) treated with a placebo for the same period. After 3 months of treatment and 2 years later after cessation of tadalafil, all patients were assessed for ED and PE. Results The mean (SD) IELT and IIEF-5 score pre-treatment were 37 (11.24) s and 13.2 (4.2) for Group I, while in Group II they were 35.98 (10.8) s and 13.12 (4.11), respectively. After 3 months of treatment, the mean (SD) IELT in Group I showed a highly significant improvement from 37 (11.24) s to 120.5 (47.37) s (P < 0.001) but Group II showed no significant improvement from baseline to [39.43 (13.6) s; P > 0.05]. For the IIEF-5 score, there was a highly significant improvement from baseline to 20.45 (4.5) in Group I (P < 0.001), while there was no significant difference in Group II from baseline to [15 (4.84); P > 0.05]. At 2 years after cessation of tadalafil, there was statistically significant improvement in the IELT and IIEF-5 from baseline to endpoint . Conclusion Oral daily 5-mg tadalafil was effective, tolerable, and safe treatment for patients with ED and PE. Long-term follow-up at 2 years confirmed the persistence of a significant improvement for both ED and PE. Abbreviations: ED: erectile dysfunction; IIEF-5: five-item version of the International Index of Erectile Function questionnaire; IELT: intravaginal ejaculatory latency time; OAD: once-daily; PDE5i: phosphodiesterase-5 inhibitors; PE: premature ejaculation; PRN: pro re nata","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"20 1","pages":"49 - 53"},"PeriodicalIF":1.3000,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arab Journal of Urology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/2090598X.2021.2024695","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

ABSTRACT Objective To evaluate the safety and effectiveness of daily 5-mg tadalafil treatment for men who have erectile dysfunction (ED) and premature ejaculation (PE), and to assess the long-term follow-up for ED and PE improvement persistence years after the cessation of medication. Patients and Methods A prospective, single-blind, randomised study included 160 patients with ED and PE. All were evaluated using the International Index of Erectile Function (IIEF-5) questionnaire to evaluate ED and intravaginal ejaculatory latency time (IELT) for PE. Patients were subdivided into two equal groups. Group I (80 patients) treated with daily 5-mg tadalafil for 3 months, and Group II (80 patients) treated with a placebo for the same period. After 3 months of treatment and 2 years later after cessation of tadalafil, all patients were assessed for ED and PE. Results The mean (SD) IELT and IIEF-5 score pre-treatment were 37 (11.24) s and 13.2 (4.2) for Group I, while in Group II they were 35.98 (10.8) s and 13.12 (4.11), respectively. After 3 months of treatment, the mean (SD) IELT in Group I showed a highly significant improvement from 37 (11.24) s to 120.5 (47.37) s (P < 0.001) but Group II showed no significant improvement from baseline to [39.43 (13.6) s; P > 0.05]. For the IIEF-5 score, there was a highly significant improvement from baseline to 20.45 (4.5) in Group I (P < 0.001), while there was no significant difference in Group II from baseline to [15 (4.84); P > 0.05]. At 2 years after cessation of tadalafil, there was statistically significant improvement in the IELT and IIEF-5 from baseline to endpoint . Conclusion Oral daily 5-mg tadalafil was effective, tolerable, and safe treatment for patients with ED and PE. Long-term follow-up at 2 years confirmed the persistence of a significant improvement for both ED and PE. Abbreviations: ED: erectile dysfunction; IIEF-5: five-item version of the International Index of Erectile Function questionnaire; IELT: intravaginal ejaculatory latency time; OAD: once-daily; PDE5i: phosphodiesterase-5 inhibitors; PE: premature ejaculation; PRN: pro re nata

查看原文本刊更多论文

每日5mg他达拉非治疗勃起功能障碍和早泄的短期和长期随访结果

摘要目的评价每日5mg他达拉非治疗男性勃起功能障碍（ED）和早泄（PE）的安全性和有效性，并评估停药后ED和早泄改善持续数年的长期随访情况。患者和方法一项前瞻性、单盲、随机研究纳入160名ED和PE患者。所有患者均使用国际勃起功能指数（IIEF-5）问卷进行评估，以评估PE的ED和阴道内射精潜伏期（IELT）。患者被分为两组。第一组（80名患者）每天服用5mg他达拉非治疗3个月，第二组（80例患者）同期服用安慰剂。治疗3个月后和停药2年后，对所有患者进行ED和PE评估。结果I组治疗前IELT和IIEF-5评分的平均值（SD）分别为37（11.24）s和13.2（4.2），而II组分别为35.98（10.8）s和13.12（4.11）。治疗3个月后，I组的平均（SD）IELT从37（11.24）s显著改善到120.5（47.37）s（P＜0.001），但II组从基线到[39.43（13.6）s没有显著改善；P＞0.05]。对于IIEF-5评分，I组从基线至20.45（4.5）有非常显著的改善（P＜001），而第II组从基线到[15（4.84）；P>0.05]没有显著差异。在停用他达拉非2年后，从基线到终点，IELT和IIEF-5有统计学显著改善。结论每日口服5mg他达拉非对ED和PE患者是有效、耐受和安全的治疗方法。2年的长期随访证实ED和PE持续显著改善。缩写：ED：勃起功能障碍；IIEF-5：国际勃起功能指数调查表的五项版本；IELT：阴道内射精潜伏期；OAD：每天一次；PDE5i：磷酸二酯酶-5抑制剂；PE：早泄；PRN：出生前

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Arab Journal of Urology UROLOGY & NEPHROLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： The Arab Journal of Urology is a peer-reviewed journal that strives to provide a high standard of research and clinical material to the widest possible urological community worldwide. The journal encompasses all aspects of urology including: urological oncology, urological reconstructive surgery, urodynamics, female urology, pediatric urology, endourology, transplantation, erectile dysfunction, and urinary infections and inflammations. The journal provides reviews, original articles, editorials, surgical techniques, cases reports and correspondence. Urologists, oncologists, pathologists, radiologists and scientists are invited to submit their contributions to make the Arab Journal of Urology a viable international forum for the practical, timely and state-of-the-art clinical urology and basic urological research.