{"title":"Prophage mediated control of higher order interactions - Insights from multi-level approaches","authors":"Carolin C. Wendling","doi":"10.1016/j.coisb.2023.100469","DOIUrl":null,"url":null,"abstract":"<div><p><span>Prophages, latent viral elements residing in </span>bacterial genomes<span> affect bacterial ecology and evolution in diverse ways. Do these prophage-mediated effects extend beyond the prophage-bacterial relationship? Here, I summarize the latest advances exploring how the impacts of prophages are transmitted through multiple levels of biological systems with potential impacts on ecosystem stability and functioning. The diverse effects of prophages on higher-order interactions are context-specific, ranging from contributions to global biogeochemical processes and mutualistic interactions to increased disease severity with negative impacts on ecosystem engineers and potential cascading effects for multiple species. While we have a solid understanding of the mechanisms by which prophages modulate their bacterial hosts at the cellular and population levels, future research may take an integrative approach to quantify their effects in complex ecosystems.</span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"35 ","pages":"Article 100469"},"PeriodicalIF":3.4000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452310023000264","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Prophages, latent viral elements residing in bacterial genomes affect bacterial ecology and evolution in diverse ways. Do these prophage-mediated effects extend beyond the prophage-bacterial relationship? Here, I summarize the latest advances exploring how the impacts of prophages are transmitted through multiple levels of biological systems with potential impacts on ecosystem stability and functioning. The diverse effects of prophages on higher-order interactions are context-specific, ranging from contributions to global biogeochemical processes and mutualistic interactions to increased disease severity with negative impacts on ecosystem engineers and potential cascading effects for multiple species. While we have a solid understanding of the mechanisms by which prophages modulate their bacterial hosts at the cellular and population levels, future research may take an integrative approach to quantify their effects in complex ecosystems.
期刊介绍：
Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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