Pharmacological potential of serially extracted Solanum xanthocarpum fruit extracts and their phytochemical characterization

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2022-05-23 DOI:10.1080/10496475.2022.2079793

Shashank Kumar, A. Pandey

引用次数: 0

Abstract

ABSTRACT Pharmacological potential of serially extracted Solanum xanthocarpum fruit (SXF) extracts in terms of antioxidant, anticancer, and antibacterial activities was evaluated. Chemical characterization of the potent extract was done by HPLC, LC-MS-MS, and GC-MS techniques. In vitro antioxidant models, viz. hydroxyl radical scavenging, metal ion chelation, total antioxidant capacity, and ferric reducing antioxidant power, were used to assess the antioxidant potential of extract. Cytotoxicity of the SXF extracts was tested against prostate, ovary, and breast cancer cell lines (DU-145, IGR-OV-1, and MCF-7) using sulforhodamine (SRB) assay. The antibacterial potential was assessed against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli bacteria. Results indicated potential pharmacological activities and the presence of pharmacologically active phytoconstituents in the SKF extracts.

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系列提取龙葵果提取物的药理潜力及其植物化学性质研究

摘要从抗氧化、抗癌和抗菌活性方面评价了连续提取的黄果提取物的药理潜力。通过HPLC、LC-MS-MS和GC-MS技术对强效提取物进行了化学表征。体外抗氧化模型，即羟基自由基清除、金属离子螯合、总抗氧化能力和铁还原抗氧化能力，用于评估提取物的抗氧化潜力。使用磺基罗丹明（SRB）检测SXF提取物对前列腺、卵巢和乳腺癌症细胞系（DU-145、IGR-OV-1和MCF-7）的细胞毒性。评估了对金黄色葡萄球菌、粪肠球菌、铜绿假单胞菌、肺炎克雷伯菌和大肠杆菌的抗菌潜力。结果表明SKF提取物具有潜在的药理活性和药理活性植物成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.