Treatment and Research Progress of Articular cartilage injury in HT3SS

中国综合临床 Pub Date : 2019-11-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.06.020

Zhongling Hu, Jiayang Wang, Yishuang Cui, Qian Wang, Hui Zhang, Qi-jia Li, Zhiqiang Wang

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Abstract

Objective Articular cartilage injury is one of the most common orthopedic diseases with high morbidity and morbidity, especially in the elderly.Articular cartilage injury causes degenerative changes of articular cartilage, such as osteoarthritis, which can lead to disability, pain during joint movement and deformation of bone and joint.The prevalence of osteoarthritis accounts for 10% ~12% of the total population in the world.It is a common disease.The prevalence of osteoarthritis has increased to 49.7% for the elderly aged over 65 years old (Statistics of the World Health Organization (who) in 2010 show that with the development of social aging and obesity and other adverse factors, these figures will continue to rise.It is known that osteoarthritis is related to aging, trauma, genetic susceptibility, obesity and inflammation, but the specific cause of osteoarthritis has not been fully identified, which leads to many obstacles in clinical treatment of osteoarthritis.At present, most of the clinical and research work in this field is focused on the restoration of cartilage trauma.In this review, we summarize and discuss the methods of cartilage defect repair, as well as the hot spots and directions of future research work. Key words: Cartilage injury; Articular cartilage defects; Osteoarthritis; Therapy

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HT3SS关节软骨损伤的治疗及研究进展

目的关节软骨损伤是骨科最常见的疾病之一，发病率高，尤其是老年人。关节软骨损伤引起关节软骨退行性改变，如骨关节炎，可导致残疾、关节运动疼痛和骨关节变形。骨关节炎的患病率占世界总人口的10% ~12%。这是一种常见病。65岁以上老年人骨关节炎患病率已上升至49.7%(世界卫生组织(who) 2010年统计数据显示，随着社会老龄化和肥胖等不利因素的发展，这些数字将继续上升。众所周知，骨关节炎与衰老、创伤、遗传易感性、肥胖和炎症有关，但骨关节炎的具体病因尚未完全确定，这导致骨关节炎的临床治疗存在许多障碍。目前，该领域的临床和研究工作大多集中在软骨损伤的修复上。本文对软骨缺损修复的方法进行了总结和讨论，并对今后的研究热点和方向进行了展望。关键词:软骨损伤;关节软骨缺损;骨关节炎;治疗

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.