Gut virome in early life: origins and implications

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2022-08-01 DOI:10.1016/j.coviro.2022.101233

Elizabeth A Kennedy , Lori R Holtz

引用次数: 5

Abstract

The human body is colonized by a multitude of bacteria, fungi, and viruses, which play important roles in health and disease. Microbial colonization during early life is thought to be a particularly important period with lasting consequences for health. Viral populations in the gut are particularly dynamic in early life before they stabilize in adulthood. The composition of the early-life virome is increasingly recognized as a determinant of disease later in life. Here, we review the development of the virome in healthy infants, as well as the role of the early-life virome in the development of disease states including diarrhea, malnutrition, and autoimmune diseases.

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早期生命中的肠道病毒:起源和意义

人体内有大量的细菌、真菌和病毒，它们在健康和疾病中起着重要的作用。生命早期的微生物定植被认为是一个特别重要的时期，对健康有持久的影响。在成年后稳定下来之前，肠道中的病毒种群在生命早期尤其活跃。生命早期病毒组的组成越来越被认为是生命后期疾病的决定因素。在这里，我们回顾了病毒体在健康婴儿中的发展，以及早期生命病毒体在疾病状态发展中的作用，包括腹泻、营养不良和自身免疫性疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.