Study on the Antifatigue Effect of Compound Amino Acid Capsules

IF 2.6 2区生物学 Q3 CELL BIOLOGY

Cellular Microbiology Pub Date : 2022-04-27 DOI:10.1155/2022/6593811

Wen-cai Huang, Hua-qiang Hui, Ji-ping Xu, Honglei Guo, Yunfeng Wang, Wei Zhu

引用次数: 0

Abstract

Supplementing amino acids was proven to relieve fatigue caused by exercise. This study explored the antifatigue effects of compound amino acid capsules (CAAC) on rats undergoing the forced swimming test (FST). CAAC augmented the endurance of FST in rats and alleviated the damage of skeletal muscle tissue and reduced the content of biochemical indicators in the serum. Furthermore, CAAC prevented skeletal muscle dysfunction in FST rats by modulating inflammation and oxidation reactions. After the treatment with CAAC, apoptosis and apoptosis-related protein and p-p65 were weakened, while the levels of SIRT1 and SIRT1/PGC-1α/Nrf2 pathway-related proteins were enhanced. The antifatigue properties of CAAC were associated with its antioxidant and anti-inflammatory capabilities, which were realized by activating the SIRT1/PGC-1α/Nrf2 pathway.

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复方氨基酸胶囊抗疲劳作用的研究

补充氨基酸被证明可以缓解运动引起的疲劳。本研究探讨了复方氨基酸胶囊（CAAC）对大鼠强迫游泳试验（FST）的抗疲劳作用。CAAC增强了大鼠FST的耐力，减轻了骨骼肌组织的损伤，降低了血清生化指标的含量。此外，CAAC通过调节炎症和氧化反应来预防FST大鼠的骨骼肌功能障碍。CAAC治疗后，细胞凋亡和凋亡相关蛋白和p-p65减弱，SIRT1和SIRT1/PGC-1α/Nrf2通路相关蛋白水平升高。CAAC的抗疲劳特性与其抗氧化和抗炎能力有关，这是通过激活SIRT1/PGC-1α/Nrf2途径实现的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Microbiology 生物-微生物学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Cellular Microbiology aims to publish outstanding contributions to the understanding of interactions between microbes, prokaryotes and eukaryotes, and their host in the context of pathogenic or mutualistic relationships, including co-infections and microbiota. We welcome studies on single cells, animals and plants, and encourage the use of model hosts and organoid cultures. Submission on cell and molecular biological aspects of microbes, such as their intracellular organization or the establishment and maintenance of their architecture in relation to virulence and pathogenicity are also encouraged. Contributions must provide mechanistic insights supported by quantitative data obtained through imaging, cellular, biochemical, structural or genetic approaches.