CYTOEPIGENETICS: DIALECTICAL REVIEW OF A SUBCELLULAR ENDO-MEMBRANOUS COORDINATION OF GENE EXPRESSION AND CELLULAR FATE

Abstract

CytoEpigenetics is a new event ontology in biochemistry. It involves the mutual interactions between the nuclear and mitochondrial genomes delivering asymmetric but equally necessary gene expression libraries that are mediated through proteome subcellular distribution via the lipid endomembranous system. There is a superimposed annotating epigenetic tailoring mechanism involving epi-transcriptional authorship, reading, and processing that must be in dynamic and kinetic communication for signaling, bioenergetics and cell fate. This mechanism requires substrates from intermediary metabolism to be used in covalent modification of DNA, RNA, and polypeptides via coordinated lipid membrane raft trafficking to support the endomembranous network.