{"title":"Ibuprofen tagged imine RT-COF-1 as customisable vehicle for controlled drug delivery application","authors":"Gagandeep Kaur, Pawan Kumar","doi":"10.1016/j.inoche.2022.110043","DOIUrl":null,"url":null,"abstract":"<div><p>Here, we have been synthesized imine linked covalent organic framework (RT-COF-1) using 1,3,5-tris(4-aminophenyl) benzene (TAPB) and 1,3,5-benzenetricarbaldehyde (BTCA) in 1:1 ratio with catalytic amount of glacial acetic acid at room temperature. Synthesized RT-COF1 has been confirmed using Powder X-ray diffraction (PXRD), Field Emission Scanning Electron Microscopy (FESEM), UV -Vis Spectroscopy, Photoluminescence Spectroscopy, Fourier transform infrared spectroscopy (FTIR), and BET Surface area analyzer. Then, synthesised RT-COF1 has been tagged to model drug i.e., ibuprofen (IBU) using simple coordination chemistry. The drug conjugated i.e., IBU@RT-COF-1 was confirmed through UV and IR spectroscopy techniques. Importantly, the lone pair of electrons on nitrogen atom present in RT-COF1 forms hydrogen bonding with the model drug molecules. Prominently, the model drug profile i.e., loading and release rate has been analysed using spectroscopic analysis.</p></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"145 ","pages":"Article 110043"},"PeriodicalIF":4.4000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganic Chemistry Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1387700322008516","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 6
Abstract
Here, we have been synthesized imine linked covalent organic framework (RT-COF-1) using 1,3,5-tris(4-aminophenyl) benzene (TAPB) and 1,3,5-benzenetricarbaldehyde (BTCA) in 1:1 ratio with catalytic amount of glacial acetic acid at room temperature. Synthesized RT-COF1 has been confirmed using Powder X-ray diffraction (PXRD), Field Emission Scanning Electron Microscopy (FESEM), UV -Vis Spectroscopy, Photoluminescence Spectroscopy, Fourier transform infrared spectroscopy (FTIR), and BET Surface area analyzer. Then, synthesised RT-COF1 has been tagged to model drug i.e., ibuprofen (IBU) using simple coordination chemistry. The drug conjugated i.e., IBU@RT-COF-1 was confirmed through UV and IR spectroscopy techniques. Importantly, the lone pair of electrons on nitrogen atom present in RT-COF1 forms hydrogen bonding with the model drug molecules. Prominently, the model drug profile i.e., loading and release rate has been analysed using spectroscopic analysis.
期刊介绍：
Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.
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