The marine natural product trichobotrysin B inhibits proliferation and promotes apoptosis of human glioma cells via the IL-6-mediated STAT3/JAK signaling pathway

Q1 Engineering
Xingliang Dai , Junjuan Fan , Dongdong Liu , Huaixu Li , Lei Shu , Peng Gao , Senhua Chen , Xianwen Wang
{"title":"The marine natural product trichobotrysin B inhibits proliferation and promotes apoptosis of human glioma cells via the IL-6-mediated STAT3/JAK signaling pathway","authors":"Xingliang Dai ,&nbsp;Junjuan Fan ,&nbsp;Dongdong Liu ,&nbsp;Huaixu Li ,&nbsp;Lei Shu ,&nbsp;Peng Gao ,&nbsp;Senhua Chen ,&nbsp;Xianwen Wang","doi":"10.1016/j.smaim.2023.08.001","DOIUrl":null,"url":null,"abstract":"<div><p>Glioma is the most common malignant tumor of the central nervous system. Drug-assisted chemotherapy is an important adjuvant treatment post-surgery, but currently, effective chemotherapy drugs for glioma are lacking. Expediting new and effective chemotherapy drugs is a persistent problem that needs to be solved. In this study, a tetramic acid derivative, trichobotrysin B, was extracted from the ascidian-derived fungus <em>Trichobotrys effusa</em> 4729 (denoted ADF<sub>Te4729</sub>). There is significant cytotoxicity of trichobotrysin B against glioma proliferation, which triggers apoptosis and cell cycle arrest. Furthermore, studies have found that trichobotrysin B inhibits glioma proliferation in a manner closely related to IL-6-mediated STAT3 phosphorylation and JAK2 activation. In conclusion, this study demonstrates that the small-molecule compound trichobotrysin B inhibits glioma proliferation and induces apoptosis through the IL-6-mediated STAT3/JAK2 signaling pathway, suggesting that trichobotrysin B has potential antiglioma efficiency and provides a new way to explore new small-molecule drugs with anticancer effects.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":"5 1","pages":"Pages 66-74"},"PeriodicalIF":0.0000,"publicationDate":"2023-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart Materials in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590183423000388","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 1

Abstract

Glioma is the most common malignant tumor of the central nervous system. Drug-assisted chemotherapy is an important adjuvant treatment post-surgery, but currently, effective chemotherapy drugs for glioma are lacking. Expediting new and effective chemotherapy drugs is a persistent problem that needs to be solved. In this study, a tetramic acid derivative, trichobotrysin B, was extracted from the ascidian-derived fungus Trichobotrys effusa 4729 (denoted ADFTe4729). There is significant cytotoxicity of trichobotrysin B against glioma proliferation, which triggers apoptosis and cell cycle arrest. Furthermore, studies have found that trichobotrysin B inhibits glioma proliferation in a manner closely related to IL-6-mediated STAT3 phosphorylation and JAK2 activation. In conclusion, this study demonstrates that the small-molecule compound trichobotrysin B inhibits glioma proliferation and induces apoptosis through the IL-6-mediated STAT3/JAK2 signaling pathway, suggesting that trichobotrysin B has potential antiglioma efficiency and provides a new way to explore new small-molecule drugs with anticancer effects.

Abstract Image

海洋天然产物木霉素B通过IL-6介导的STAT3/JAK信号通路抑制人脑胶质瘤细胞增殖并促进细胞凋亡
神经胶质瘤是中枢神经系统最常见的恶性肿瘤。药物辅助化疗是胶质瘤术后重要的辅助治疗手段,但目前缺乏有效的胶质瘤化疗药物。加速开发新的有效的化疗药物是一个长期需要解决的问题。本研究从海鞘源真菌Trichobotrys effusa 4729(编号ADFTe4729)中提取了一种四酸衍生物trichobotrysin B。trichobotrysin B对胶质瘤增殖具有显著的细胞毒性,可引发细胞凋亡和细胞周期阻滞。此外,研究发现,trichobotrysin B抑制胶质瘤增殖的方式与il -6介导的STAT3磷酸化和JAK2激活密切相关。综上所述,本研究表明,小分子化合物trichobotrysin B通过il -6介导的STAT3/JAK2信号通路抑制胶质瘤增殖并诱导细胞凋亡,提示trichobotrysin B具有潜在的抗胶质瘤作用,为探索具有抗癌作用的新型小分子药物提供了新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信