The marine natural product trichobotrysin B inhibits proliferation and promotes apoptosis of human glioma cells via the IL-6-mediated STAT3/JAK signaling pathway

Q1 Engineering
Xingliang Dai , Junjuan Fan , Dongdong Liu , Huaixu Li , Lei Shu , Peng Gao , Senhua Chen , Xianwen Wang
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引用次数: 1

Abstract

Glioma is the most common malignant tumor of the central nervous system. Drug-assisted chemotherapy is an important adjuvant treatment post-surgery, but currently, effective chemotherapy drugs for glioma are lacking. Expediting new and effective chemotherapy drugs is a persistent problem that needs to be solved. In this study, a tetramic acid derivative, trichobotrysin B, was extracted from the ascidian-derived fungus Trichobotrys effusa 4729 (denoted ADFTe4729). There is significant cytotoxicity of trichobotrysin B against glioma proliferation, which triggers apoptosis and cell cycle arrest. Furthermore, studies have found that trichobotrysin B inhibits glioma proliferation in a manner closely related to IL-6-mediated STAT3 phosphorylation and JAK2 activation. In conclusion, this study demonstrates that the small-molecule compound trichobotrysin B inhibits glioma proliferation and induces apoptosis through the IL-6-mediated STAT3/JAK2 signaling pathway, suggesting that trichobotrysin B has potential antiglioma efficiency and provides a new way to explore new small-molecule drugs with anticancer effects.

Abstract Image

海洋天然产物木霉素B通过IL-6介导的STAT3/JAK信号通路抑制人脑胶质瘤细胞增殖并促进细胞凋亡
神经胶质瘤是中枢神经系统最常见的恶性肿瘤。药物辅助化疗是胶质瘤术后重要的辅助治疗手段,但目前缺乏有效的胶质瘤化疗药物。加速开发新的有效的化疗药物是一个长期需要解决的问题。本研究从海鞘源真菌Trichobotrys effusa 4729(编号ADFTe4729)中提取了一种四酸衍生物trichobotrysin B。trichobotrysin B对胶质瘤增殖具有显著的细胞毒性,可引发细胞凋亡和细胞周期阻滞。此外,研究发现,trichobotrysin B抑制胶质瘤增殖的方式与il -6介导的STAT3磷酸化和JAK2激活密切相关。综上所述,本研究表明,小分子化合物trichobotrysin B通过il -6介导的STAT3/JAK2信号通路抑制胶质瘤增殖并诱导细胞凋亡,提示trichobotrysin B具有潜在的抗胶质瘤作用,为探索具有抗癌作用的新型小分子药物提供了新的途径。
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来源期刊
Smart Materials in Medicine
Smart Materials in Medicine Engineering-Biomedical Engineering
CiteScore
14.00
自引率
0.00%
发文量
41
审稿时长
48 days
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