Viscum monoicum: A New Source of Polyphenolic Compounds Responsible for Antioxidant and Anti-Inflammatory Activities

IF 1.2 Q4 PHARMACOLOGY & PHARMACY
K. S. Ahmed, M. Farzana, S. E. Rahman, I. Jahan, T. Khan, M. A. Al-Mansur, Nadia Sultana, Hemayet Hossain
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引用次数: 1

Abstract

ABSTRACT Viscum monoicum has been used as a traditional medicinal plant for the treatment of many ailments that include pain, neuropharmacological disorders as well as various types of tumors. This study was designed to investigate the polyphenolic compound, antioxidant, and anti-inflammatory activities of the ethanolic extract of Viscum monoicum (EVM). The extract was subjected to HPLC-DAD analysis for the quantification of polyphenols. In addition, DPPH, ABTS free radical scavenging, reducing power, total antioxidant capacity, phenolic, and flavonoid content was measured for antioxidant activities of EVM. Besides, the anti-inflammatory activity of EVM was studied using carrageenan and histamine-induced rat paw edema at different doses. High levels of ellagic acid and (+)-catechin hydrate (410.15 and 340.88 mg/100 g extract, respectively) were determined for the first time through HPLC in EVM. IC50 of EVM was significant in DPPH and ABTS scavenging assay compared to that of ascorbic acid. The total antioxidant capacity, total phenolic, and total flavonoid contents were estimated and found significant amount equivalent to standard. At a dose of 400 mg kg−1, a significant anti-inflammatory activity (P<0.01) was observed in rats at both carrageenan and histamine-induced edema test models with a reduction in the paw volume; in comparison to indomethacin. Therefore, the results suggest that polyphenolic compounds might be responsible for the antioxidant and anti-inflammatory activities of EVM.
一种具有抗氧化和抗炎活性的多酚类化合物的新来源
摘要:苦楝是一种传统的药用植物,用于治疗许多疾病,包括疼痛、神经药理障碍以及各种类型的肿瘤。摘要本研究旨在研究葡萄醇提物(EVM)的多酚类化合物、抗氧化和抗炎活性。提取液采用HPLC-DAD法测定多酚含量。此外,测定了EVM抗氧化活性的DPPH、ABTS自由基清除能力、还原能力、总抗氧化能力、酚类和类黄酮含量。此外,采用不同剂量的卡拉胶和组胺诱导大鼠足跖水肿,研究EVM的抗炎活性。在EVM中首次检测到高含量的鞣花酸和(+)-儿茶素(分别为410.15和340.88 mg/100 g)。与抗坏血酸相比,EVM在DPPH和ABTS清除试验中的IC50显著。对其总抗氧化能力、总酚和总黄酮含量进行了测定,发现其含量与标准相当。在400 mg kg - 1剂量下,卡拉胶和组胺诱导的大鼠水肿模型均有显著的抗炎活性(P<0.01),且足部体积减小;与吲哚美辛相比。因此,多酚类化合物可能与EVM的抗氧化和抗炎活性有关。
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来源期刊
Journal of Herbs, Spices and Medicinal Plants
Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine
CiteScore
3.00
自引率
0.00%
发文量
36
期刊介绍: The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.
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