Panax Ginseng Inhibits Maximal Electroshock Induced Convulsions in Mice

Abstract

Epilepsy is a serious common neurological disease. Panax ginseng root has been identified as a potential therapy for many disorders. The present study investigated the possible anticonvulsant activity of Panax ginseng on maximal electroshock (MES) induced seizure in mice. Mice were divided into the following groups: Group A (control group): injected with normal saline then exposed to electric shock. Group B (test group): injected with sodium valproate (300 mg/kg, 600 mg/kg, 900 mg/kg). Then exposed to electric shock. Group C (test group): injected with Panax Ginseng (150, 250, 350 mg/kg) then exposed to electric shock. All animals were examined for motor coordination on rotarod test. We concluded that P. ginseng at moderate and high doses significantly decreased the HLE duration of convulsion in mice, denoting that P. ginseng has anticonvulsant effects. the antiepileptic activity of P. ginseng might be due to its antioxidative actions, anti-inflammatory, its regulating effect on sodium ion channels and/or due to its possible modulation of GABA receptor channel activity for further investigations.