Increased Risk of Hypertension in Alcohol Use Disorder of alcohol-related Liver disease-A Hospital Based Case Control Study

IF 0.6 Q4 SUBSTANCE ABUSE

Alcoholism Treatment Quarterly Pub Date : 2022-10-17 DOI:10.1080/07347324.2022.2135472

Prabhudas Nelaturi, S. P. Kademani, Vithiavathi Siva Subramanian, S. Ravikumar

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Abstract

ABSTRACT Hypertension is one of the leading causes of morbidity and mortality worldwide. Prevalence is reported to be 26% and may increase by 29.2% in 2025. Consumption of alcohol, increased BMI and metabolic syndrome are the main causal factors of risk of hypertension. The interrelationship between alcohol use disorder and the risk of hypertension-related mortality in alcohol-related liver disease (ALD) is increasingly acknowledged. The study intended to address the health issue regarding alcohol use disorder and the risk of development of hypertension in ALD. This is a hospital-based prospective case-control study. A total of 139 study subjects were enrolled, of which 62 were ALD, and 77 were nonalcoholic fatty liver disease (NAFLD). Diagnosed progression of liver disease based on scoring method. The Chi-square test and independent-sample t-test were used for categorical variables and baseline characteristics, respectively. We observed 67 (48.20%) and 46 (33.09%) incident cases of hypertension in subjects with ALD and NAFLD, respectively. The prevalence of hypertension between the groups of ALD and NAFLD was statistically significant [P = .0017; OR 4.855 (95% CI: 1.810–13.020)]. Gradual increase in the incidence of hypertension in patients with ALD was observed due to alcohol use disorder, obesity, and metabolic syndrome.

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酒精相关肝病酒精使用障碍中高血压风险增加——一项基于医院的病例对照研究

摘要高血压是全球发病率和死亡率的主要原因之一。据报道，患病率为26%，到2025年可能增加29.2%。饮酒、BMI增加和代谢综合征是高血压风险的主要原因。酒精使用障碍与酒精相关肝病（ALD）中高血压相关死亡风险之间的相互关系越来越得到认可。该研究旨在解决酒精使用障碍和ALD患者患高血压风险的健康问题。这是一项基于医院的前瞻性病例对照研究。共有139名研究受试者入选，其中62名为ALD，77名为非酒精性脂肪性肝病（NAFLD）。基于评分法诊断肝病进展。分类变量和基线特征分别采用卡方检验和独立样本t检验。我们在ALD和NAFLD受试者中分别观察到67例（48.20%）和46例（33.09%）高血压事件。ALD组和NAFLD组的高血压患病率具有统计学意义[P=.0017；OR 4.855（95%CI:1.810–13.020）]。由于酒精使用障碍、肥胖和代谢综合征，ALD患者的高血压发病率逐渐增加。

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来源期刊

Alcoholism Treatment Quarterly SUBSTANCE ABUSE-

CiteScore

1.60

自引率

11.10%

发文量

期刊介绍： Alcoholism Treatment Quarterly is an exciting professional journal for clinicians working with persons who are alcoholic and their families. Designed to bridge the gap between research journals and information for the general public, it addresses the specific concerns of professional alcoholism counselors, social workers, psychologists, physicians, clergy, nurses, employee assistance professionals, and others who provide direct services to persons who are alcoholic. The journal features articles specifically related to the treatment of alcoholism, highlighting new and innovative approaches to care, describing clinical problems and solutions, and detailing practical, unique approaches to intervention and therapy.