Jihong Hao, Jie Gao, Yiping Yang, Ziyi An, Xiaoqiang Lian
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引用次数: 0
Abstract
could be observed in the cytoplasm or covering the nuclei in lymphocytes (Figures 1A-1D). Abdominal computed tomography showed multiple enlarged lymph nodes in the abdomen and groin. Flow cytometry analysis revealed the expression of CD19, CD20, CD5, CD22, CD23, CD24, CD38, lambda, FCM7 (dim, 38.6%), and CD200 (high). Previous studies have suggested that the formation of crystals may be related to dysfunctional immunoglobulin (Ig) synthesis [1,2,3,4]. In our case, the levels of IgG, IgA, and IgM were all reduced, with the most significant reduction seen for IgG at 4.96 g/L. While some observations of similar rod-like structures have been reported in cases of B-cell lymphoproliferative diseases, intracellular rod-like crystals in mature lymphocytes in CLL are extremely rare in peripheral blood [5,6,7]. Here, the crystals in the lymphocytes were present after anti-leukemia therapy. Whether the formation of these crystals may be related to chemotherapy drugs needs to be confirmed.
期刊介绍:
The Turkish Journal of Hematology is published quarterly (March, June, September, and December) by the Turkish Society of Hematology. It is an independent, non-profit peer-reviewed international English-language periodical encompassing subjects relevant to hematology.
The Editorial Board of The Turkish Journal of Hematology adheres to the principles of the World Association of Medical Editors (WAME), International Council of Medical Journal Editors (ICMJE), Committee on Publication Ethics (COPE), Consolidated Standards of Reporting Trials (CONSORT) and Strengthening the Reporting of Observational Studies in Epidemiology (STROBE).
The aim of The Turkish Journal of Hematology is to publish original hematological research of the highest scientific quality and clinical relevance. Additionally, educational material, reviews on basic developments, editorial short notes, images in hematology, and letters from hematology specialists and clinicians covering their experience and comments on hematology and related medical fields as well as social subjects are published. As of December 2015, The Turkish Journal of Hematology does not accept case reports. Important new findings or data about interesting hematological cases may be submitted as a brief report.