Correction of natural resistance indicators in calves with abomazoenteritis

L. Slivinska, H. Zinko, V. Vlizlo, M. Lychuk, A. Shcherbatyy, B. Lukashchuk, V. Fedorovucj
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Abstract

Diseases of the digestive system, especially of ounganimals, are widespread and cause significant material lossesto farms of all types of property. Therefore, it is importantto develop a complex treatment that affects all links ofpathogenesis, accelerates recovery and at the same timedoes not have a toxic effect on the body of young animals.There search was carried out in the farms of the Lviv region on black-and-white calves at the age of 1.5–2 months of age.The animals of the research groups were diagnosed withabomazoenteritis. Clinically healthy animal analogs served ascontrol. It was previously established that in calves patientswith abomazoenteritis, the bactericidal activity of bloodserum (BABS), lysozyme activity of blood serum (LABS)and indicators of the activity of phagocytosis of neutrophilsdecrease. The animals were treated with diet, antibiotic therapy,rehydration and vitamin therapy. In addition, the calves of oneof the research groups received the oral drug Selenium (SelPlex) and the intramuscular drug Germanium (Maxidin 0.4)as antioxidants and immunomodulators. The dat aobtained byus indicate that the use of these drugs in the complex therapyof patients with abomazoenteritis of calves contributed to theacceleration of the clinical recovery of calves (on average by2 days). The positive effect of the Selenium and Germaniumpreparations on the indices of nonspecific resistance was alsoestablished: BABS and LABS on the seventh day of the studywere higher (p<0.001) than in animals to which these drugswere not used and amounted to 41.0±0.51 and 19.5±0.45 %respectively. Similar changes were revealed as indicatorsof phagocytosis. Phagocytic activity of neutrophils (FA)was higher than the third (p<0.05), seventh (p<0.01) andfourteenth (p<0.01) days of the study. The phagocytic index(PI) of the seventh (p<0.001) and the fourteenth (p<0.001)day of research compared with the group of animals whereSelenium and Germanium were not used. The studies carriedout indicate that the use of Sel-Plex and Maxid in 0.4 in thecomplex treatment of calves with abomazoenteritis acceleratedthe recovery of animals, in particular through a positive effecton the indices of nonspecific resistance. Key words: younganimals, digestive disorders,Selenium, Germanium, phagocytosis, bactericidal, lysozymeactivity of blood serum.
小牛abomazoneceritis自然抗性指标的校正
消化系统疾病,尤其是无组织疾病,在各种性质的农场中都很普遍,并造成重大的物质损失。因此,重要的是开发一种复杂的治疗方法,它可以影响疾病发生的各个环节,加速康复,同时不会对幼兽的身体产生毒性影响。在利沃夫地区的农场对1.5至2个月大的黑白幼崽进行了搜索。研究组的动物被诊断为睑板炎。临床上健康的动物类似物作为对照。先前已经确定,在患有abomazoneceritis的小牛患者中,血液的杀菌活性(BABS)、血清的溶菌酶活性(LABS)和中性粒细胞吞噬活性的指标增加。动物接受饮食、抗生素治疗、补液和维生素治疗。此外,其中一个研究小组的小牛接受了口服药物硒(SelPlex)和肌肉注射药物锗(Maxidin 0.4)作为抗氧化剂和免疫调节剂。我们获得的数据表明,在小牛abomazoneceritis患者的复杂治疗中使用这些药物有助于加速小牛的临床康复(平均2天)。硒和锗补偿对非特异性耐药性指标的积极作用也得到了证实:研究第7天的BABS和LABS高于未使用这些药物的动物(p<0.001),分别为41.0±0.51和19.5±0.45%。类似的变化也显示为吞噬作用的指标。中性粒细胞(FA)的吞噬细胞活性高于研究的第三天(p<0.05)、第七天(p<0.01)和第十四天(p<0.01)。与未使用硒和锗的动物组相比,研究第七天(p<0.001)和第十四天(p>0.001)的吞噬指数(PI)。所进行的研究表明,在患有abomazoneceritis的小牛的综合治疗中使用Sel-Plex和Maxid 0.4可以加速动物的恢复,特别是通过对非特异性耐药性指数的积极影响。关键词:青年、消化系统疾病、硒、锗、吞噬细胞、杀菌、血清溶菌酶活性。
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