Synthesis and fungicidal activities of 2-{[(2-(1H-1,2,4-triazol-1-yl)-ethylidene)amino]oxy}alkanamides containing dihydrobenzofuran

IF 2.1 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2018-12-19 DOI:10.1515/hc-2017-0245

L. Wan, Yang Zihui, Huang Aixi, Ye Jiao, Xiaoming Ou, Pei Hui, He Lian, Jianming Li

引用次数: 1

Abstract

Abstract In order to find new compounds with high fungicidal activity, acetamide derivatives 4a–x were rationally designed, synthesized, characterized and tested against various fungi in vivo. The bioassay results indicate that compounds 4k,m,o,r exhibit an 80% inhibition rate against Rhizoctonia solani at 500 mg/L, and compound 4j shows an 80% inhibition rate against Blumeria graminis at 500 mg/L. Therefore, compounds of 4 are promising fungicidal candidates worthy of further development.

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含二氢苯并呋喃的2-{(2-(1h -1,2,4-三唑-1-基)-乙基)氨基]氧}烷酰胺的合成及杀菌活性

摘要为了寻找具有高杀菌活性的新化合物，对乙酰胺衍生物4a–x进行了合理的设计、合成、表征和体内抗真菌试验。生物测定结果表明，化合物4k、m、o、r在500mg/L下对立枯丝核菌的抑制率为80%，化合物4j在500mg/L时对禾白菌的抑制效率为80%。因此，4的化合物是有前景的杀真菌候选物，值得进一步开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.