Fibrinogen and/or Fibrin as a Cause of Neuroinflammation.

Abstract

Involvement of Fibrinogen(Fg) and fibrin during various pathologies associated with neuroinflammatory diseases associated with memory reduction are well known. Elevated level of Fg, called hyperfibrinogenemia (HFg) (e.g. ≥ 4±0.1 mg/ml of plasma during inflammation vs.~2±0.1 mg/ml of normal plasma [1]), accompanies inflammatory diseases such as stroke [2,3], hypertension [1,4], diabetes [5] and Traumatic Brain Injury (TBI) [6-9]. Blood level of Fg increases during inflammation in general [10].